Abstract Details

Title The International Incidence and Prevalence of Neurological Diseases - Do We Really Know How Common Neurological Conditions Are? Challenges in Interpreting International Epidemiological Studies

Topic Global Health

Presentation(s) IN6 - (-)

Poster/Presentation
Number 002

Objective

Background In 2009, the Canadian National Population Study of Neurological Conditions was launched. One of its aims was to examine the epidemiology of 15 conditions [Alzheimer's disease/related dementias, amyotrophic lateral sclerosis (ALS), brain tumours, cerebral palsy (CP), dystonia, epilepsy, Huntington disease, hydrocephalus, multiple sclerosis, muscular dystrophy (MD), Parkinson's disease, spina bifida, spinal cord injury (SCI), Tourette syndrome and traumatic brain injury (TBI)].

Design/Methods Systematic reviews with meta-analysis (where appropriate) of population-based studies reporting on the incidence and/or prevalence of all conditions were conducted. Data were abstracted and study quality assessed in duplicate. Study heterogeneity was examined descriptively (variation in methods of ascertainment, diagnostic criteria, etc.) and using the I2 statistic.

Results [sim]65,000 abstracts and 4,663 articles were reviewed, with data abstracted on >1280 articles (n=16 for dystonia to >200 for spina bifida). Incidence studies were less frequently performed than prevalence studies except for SCI and TBI (few prevalence studies). Within conditions, methodology (ascertainment methods, age group included) and estimates differed substantially between studies. The I2 was lowest for Duchenne MD prevalence in children (67%), ALS incidence (83.6%) and CP prevalence (89.5%) but >90% for most other conditions studied. Study heterogeneity (meta-regressions) and the challenges this poses to the international comparability of data will be discussed.

Conclusions Significant inconsistencies exist in methodology between epidemiological studies of neurological conditions, resulting in widely differing estimates, even between countries of similar socioeconomic status. There is a need to establish widely accepted standards for epidemiological research on neurological conditions. This would include recommendations regarding common data elements that should be collected and suggested methods of ascertainment and reporting of results.

Authors/Disclosures
Nathalie Jette, MD, MSc, FRCPC, FAAN (University of Calgary) PRESENTER	Dr. Jette has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for ILAE Epilepsia. The institution of Dr. Jette has received research support from NIH. The institution of Dr. Jette has received research support from AES.
Tamara M. Pringsheim, MD, FAAN (Mathison Centre)	The institution of Dr. Pringsheim has received research support from Canadian Institutes of Health Research. The institution of Dr. Pringsheim has received research support from Azrieli Accelerator.
	No disclosure on file
Kimford J. Meador, MD, FAAN (Stanford University School of Medicine)	The institution of Dr. Meador has received research support from NIH. The institution of Dr. Meador has received research support from Eisai. The institution of Dr. Meador has received research support from Medtronics. The institution of Dr. Meador has received research support from The Epilepsy Consortium.
Paula De Robles, MD (University of Calgary)	No disclosure on file
	No disclosure on file
Mark Hamilton, MD (Foothills Hospital, Dept of Neurosurgery)	Dr. Hamilton has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Integra Canada. The institution of Dr. Hamilton has received research support from Hydrocephalus Association.
	No disclosure on file
Lawrence Korngut, MD	Dr. Korngut has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Biogen. Dr. Korngut has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Mitsubishi Tanabe. Dr. Korngut has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Roche.
Churl-Su Kwon, MBBS (Columbia University)	Dr. Kwon has nothing to disclose.
	No disclosure on file
Jean K. Mah, MD, FRCPC, FAAN (University of Calgary)	Dr. Mah has nothing to disclose.
Ruth-Ann Marrie, MD, PhD (University of Manitoba)	The institution of Dr. Marrie has received research support from CIHR. The institution of Dr. Marrie has received research support from MS Canada. The institution of Dr. Marrie has received research support from National MS Society. The institution of Dr. Marrie has received research support from Crohn's and Colitis Canada. The institution of Dr. Marrie has received research support from US Department of Defense. The institution of Dr. Marrie has received research support from The Arthritis Society. The institution of Dr. Marrie has received research support from CMSC.
	No disclosure on file
	No disclosure on file
Maryam Oskoui, MD, FAAN (Montreal Children's Hospital - McGill University Health Centre)	Dr. Oskoui has received personal compensation in the range of $500-$4,999 for serving as an officer or member of the Board of Directors for the Association des Neurologues du Quebec. The institution of Dr. Oskoui has received research support from Hoffmann-La Roche Ltd. The institution of Dr. Oskoui has received research support from Muscular Dystrophy Canada. The institution of Dr. Oskoui has received research support from Canadian Institutes of Health Research. The institution of Dr. Oskoui has received research support from Santhera. The institution of Dr. Oskoui has received research support from Novartis. Dr. Oskoui has a non-compensated relationship as a Member of the Medical and Scientific Advisory Committee with Muscular Dystrophy Canada that is relevant to AAN interests or activities.
Scott Patten, PhD (Univ of Calgary, Community Health Sciences)	Dr. Patten has received personal compensation in the range of $10,000-$49,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Canadian Psychiatric Association. Dr. Patten has received publishing royalties from a publication relating to health care.
Dawn M. Pearson, MD (Alberta Neurologic Centre)	No disclosure on file
Aylin Reid, MD, PhD (University Health Network)	No disclosure on file
Eric E. Smith, MD (University of Calgary)	Dr. Smith has received personal compensation in the range of $10,000-$49,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for American Heart Association. Dr. Smith has received publishing royalties from a publication relating to health care. Dr. Smith has received publishing royalties from a publication relating to health care.
Thomas D. Steeves, MD (Vassar Brothers Medical Center)	No disclosure on file
	No disclosure on file
Samuel Wiebe, MD (Foothills Medical Centre)	Dr. Wiebe has a non-compensated relationship as a Past President with International League Against Epilepsy that is relevant to AAN interests or activities.
Jonathan Dykeman	No disclosure on file

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