Abstract Details

Title Effects of Aging and Gender on Brain Intrinsic Functional Connectivity: A Resting State Study in a Large Cohort of Healthy Subjects

Topic Aging and Dementia

Presentation(s) IN8 - (-)

Poster/Presentation
Number 002

Objective

Background Previous studies demonstrated a decreased brain RS FC with aging. Differences of RS FC were also shown between men and women. However, the combined effects of aging and gender on RS FC have not been investigated yet.

Design/Methods RS fMRI data were acquired from 285 right-handed healthy controls (148/137 men/women, range=8-79 years). Independent component analysis was used to identify functionally relevant RSNs. The Functional network connectivity (FNC) toolbox was used to assess significant connectivity among networks. SPM8 and ANCOVA models were used to assess correlations of RS FC with aging in men and women, corrected for regional gray matter volume. Effects of aging and age-by-gender interactions on connectivity among networks were also assessed.

Results The sensorimotor and auditory networks showed a distributed pattern of FC decrease with aging in both genders. Conversely, age-related changes in visual networks were relatively modest. In the default mode network, FC changes of the parietal lobe were detected, whereas FC changes in the salience and executive networks mainly involved the frontal lobe. In the working memory networks, there was an ipsilateral decrease and contralateral increase of RS FC with aging. In the attention network, parietal FC changes were more evident in men than in women. FNC was mainly increased with aging in both genders. There was a prevalent involvement of the sensory and the attention networks in men; and a prevalent involvement of the sensory and working memory networks in women.

Conclusions Vulnerability to aging was detected in almost all RSNs with potential functional relevance. However, age and gender effects were variable across networks. Our results might contribute to the understanding of gender-related differences in the pathobiology of aging.

Authors/Disclosures
Paola Valsasina PRESENTER	No disclosure on file
Maria A. Rocca (Neuroimaging Research Unit)	Maria Assunta Rocca has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Biogen, Bristol Myers Squibb, Eli Lilly, Janssen, Roche. Maria Assunta Rocca has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for AstraZaneca, Biogen, Bristol Myers Squibb, Bromatech, Celgene, Genzyme, Horizon Therapeutics Italy, Merck Serono SpA, Novartis, Roche, Sanofi and Teva. The institution of Maria Assunta Rocca has received research support from MS Society of Canada, the Italian Ministry of Health, the Italian Ministry of University and Research, and Fondazione Italiana Sclerosi Multipla.
	No disclosure on file
Andrea Falini	No disclosure on file
Federica Agosta (San Raffaele Scientific Institute)	Federica Agosta has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Philips. Federica Agosta has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Elsevier INC.
Giancarlo Comi, MD (University Vita-Salute)	Dr. Comi has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Janssen. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Bristol Myers Squibb. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Novartis. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Janssen. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Bristol Myers Squibb. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Novartis. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Aspen Healthcare. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Sanofi. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Sanofi. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Rewind.
Massimo Filippi, MD, FAAN (Ospedale San Raffaele, Neuroimaging Research Unit)	Dr. Filippi has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Alexion, Almirall, Biogen, Merck, Novartis, Roche, Sanofi. Dr. Filippi has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Alexion, Biogen, Bristol-Myers Squibb, Merck, Novartis, Roche, Sanofi, Sanofi-Aventis, Sanofi-Genzyme, Takeda. Dr. Filippi has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Bayer, Biogen, Celgene, Chiesi Italia SpA, Eli Lilly, Genzyme, Janssen, Merck-Serono, Neopharmed Gentili, Novartis, Novo Nordisk, Roche, Sanofi, Takeda, and TEVA. Dr. Filippi has received personal compensation in the range of $10,000-$49,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Springer Nature. The institution of Dr. Filippi has received research support from Biogen Idec, Merck-Serono, Novartis, Roche, the Italian Ministry of Health, the Italian Ministry of University and Research, and Fondazione Italiana Sclerosi Multipla.
Rachelle S. Doody, MD, PhD	Dr. Doody has received personal compensation for serving as an employee of F. Hoffman-LaRoche. Dr. Doody has stock in F. Hoffman-LaRoche.

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