Abstract Details

Title Detecting Dopaminergic Deficits in Individuals at Risk for Parkinsonism

Topic Movement Disorders

Presentation(s) IN2 - (-)

Poster/Presentation
Number 006

Objective

Background Individuals with iRBD and GBA are at higher risk for developing PD. Thus an improved understanding about clinical features or imaging surrogates that improve that ability to predict the change of state would be a useful advance in the field.

Design/Methods DaTSCAN and 3T MRI imaging studies were performed in a cohort of control, GBA, PD, and iRBD subjects who were evaluated clinically by using subdomains of the Cogstate, the Montreal Cognitive Assessment (MoCA), Brief Smell Identification test (B-SIT), the Unified Parkinson Disease Rating Scale (UPDRS), Hoehn & Yahr (H&Y), RBDQ-HK, and Epworth sleepiness scale. RBD subjects were also evaluated by the Minnesota Parasomnia injury scale.

Results We have demonstrated evidence of dopaminergic denervation in a subset of our iRBD subjects.

Conclusions A multi-modality approach appears to provide evidence of premotor features of PD in a subset of individuals at risk for developing PD.

Authors/Disclosures
Paul J. Tuite, MD, FAAN (University of Minnesota) PRESENTER	The institution of Dr. Tuite has received research support from NIH. The institution of Dr. Tuite has received research support from NIH. The institution of Dr. Tuite has received research support from NIH. The institution of Dr. Tuite has received research support from Bristol-Myers Squibb.
Michael J. Howell, MD, FAAN	Dr. Howell has received personal compensation in the range of $10,000-$49,999 for serving as an officer or member of the Board of Directors for GEM Health. Dr. Howell has stock in Sleep Performance Institute. The institution of Dr. Howell has received research support from National Institutes of Health. Dr. Howell has received publishing royalties from a publication relating to health care.
Laura S. Hemmy, PhD (University of Minnesota)	No disclosure on file
	No disclosure on file
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