Abstract Details

Title DaTscan Findings in Patients with Mild Cognitive Impairment, Alzheimer's Disease and Dementia with Lewy Bodies

Topic Aging and Dementia

Presentation(s) IN3 - (-)

Poster/Presentation
Number 008

Objective

Background Reduced striatonigral uptake on DaTscan reflects dopamine deficiency, and this finding is typical of DLB. One would predict that MCI patients with negligible parkinsonism but who have other features suggesting underlying Lewy body disease (LBD) pathology [eg, REM sleep behavior disorder or (RBD) and/or nonamnestic MCI (naMCI)] will have reduced striatonigral uptake compared to those with AD or amnestic MCI (aMCI), but uptake in AD and MCI will be greater than in DLB.

Design/Methods DaTscan imaging was performed 3-6 hours after injection of 3-5 mCI of 123I Ioflupane (DaTscan). ROIs were placed over the right and left putamen of each subject. Identical ROIs were placed over ipsilateral occipital cortical tissue. The means of the right and left putamen to occipital ratios (mPOR) of uptake for each patient were analyzed.

Results 25 subjects (mean age 71 years, 23 male) have undergone DaTscan. UPDRS scores are higher in DLB compared to MCI and AD. The mPOR ± SD for each syndrome is MCI (n=8): 2.00 ± 0.53 [aMCI (n=3): 2.33 ± 0.24, naMCI (n=5): 1.80 ± 0.57], AD (n=5): 2.59 ± 0.57, and DLB (n=12): 1.27 ± 0.27. All naMCI and DLB subjects and 1 aMCI had RBD. Using a mPOR of 2.1, all RBD cases but 1 had values <2.1.

Conclusions As predicted, the striatonigral uptake is lowest in DLB and highest in AD. Uptake in those with naMCI and/or RBD is more similar to DLB while those with aMCI and/or absence of RBD is more similar to AD. Further work in much larger numbers of MCI subjects (with an adequate number of females) will determine the potential utility of DaTscan in differentiating underlying LBD from AD in those with MCI.

Authors/Disclosures
Bradley F. Boeve, MD, FAAN (Mayo Clinic) PRESENTER	Dr. Boeve has received personal compensation in the range of $10,000-$49,999 for serving as an officer or member of the Board of Directors for Rainwater Charitable Foundation. The institution of Dr. Boeve has received research support from Alector. The institution of Dr. Boeve has received research support from EIP Pharma. The institution of Dr. Boeve has received research support from Transposon. The institution of Dr. Boeve has received research support from Cognition Therapeutics. Dr. Boeve has received publishing royalties from a publication relating to health care.
Val J. Lowe, MD (Mayo Clinic)	Dr. Lowe has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for AVID Radiopharmaceutical. Dr. Lowe has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Eisai Inc. The institution of Dr. Lowe has received research support from AVID Radiopharmaceuticals.
Kejal Kantarci, MD (Mayo Clinic)	The institution of Dr. Kantarci has received research support from Eli Lilly. The institution of Dr. Kantarci has received research support from NIH. The institution of Dr. Kantarci has received research support from ADDF.
Tanis J. Ferman, PhD (Mayo Clinic Jacksonville)	Ms. Ferman has nothing to disclose.
Michael Silber, MB, ChB, FAAN (Mayo Clinic)	Dr. Silber has received publishing royalties from a publication relating to health care. Dr. Silber has received personal compensation in the range of $500-$4,999 for serving as a Topic writer with UpToDate.
Erik K. St. Louis, MD (Mayo Clinic)	The institution of Dr. St. Louis has received research support from NIH. Dr. St. Louis has received publishing royalties from a publication relating to health care. Dr. St. Louis has received publishing royalties from a publication relating to health care.
	No disclosure on file
Robert J. Ivnik, PhD (Psychology Division (West 11-B))	No disclosure on file
David S. Knopman, MD, FAAN (Mayo Clinic)	Dr. Knopman has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for DIAN TU study. The institution of Dr. Knopman has received research support from NIH.
Bianca Weinstock-Guttman, MD (Department of Neurology, University At Buffalo)	Dr. Weinstock-Guttman has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Biogen. Dr. Weinstock-Guttman has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Genentech. Dr. Weinstock-Guttman has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Novartis . Dr. Weinstock-Guttman has received personal compensation in the range of $500-$4,999 for serving as a Consultant for EMD Serono. Dr. Weinstock-Guttman has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Abbvie. Dr. Weinstock-Guttman has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Genzyme &Sanofi. Dr. Weinstock-Guttman has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Janssen . Dr. Weinstock-Guttman has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Bayer. Dr. Weinstock-Guttman has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Horizon. Dr. Weinstock-Guttman has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Genentech. Dr. Weinstock-Guttman has received personal compensation in the range of $0-$499 for serving on a Scientific Advisory or Data Safety Monitoring board for Novartis. Dr. Weinstock-Guttman has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Biogen. Dr. Weinstock-Guttman has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Janssen. Dr. Weinstock-Guttman has received personal compensation in the range of $0-$499 for serving as a Reviewer with NIH.
Clifford R. Jack, Jr., MD (Mayo Clinic)	The institution of Dr. Jack has received research support from NIH. The institution of Dr. Jack has received research support from Alexander Family Alzheimer's Disease Research Professorship of the Mayo Clinic.
Ronald C. Petersen, MD, PhD, FAAN (Mayo Clinic)	Dr. Petersen has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Roche. Dr. Petersen has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Genentech. Dr. Petersen has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Eli Lilly and Co.. Dr. Petersen has received personal compensation in the range of $0-$499 for serving as a Consultant for Eisai, Inc.. Dr. Petersen has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Novo Nordisk. Dr. Petersen has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Novartis. Dr. Petersen has received publishing royalties from a publication relating to health care. Dr. Petersen has received publishing royalties from a publication relating to health care. Dr. Petersen has received publishing royalties from a publication relating to health care. Dr. Petersen has a non-compensated relationship as a Board of Directors with American Brain Foundation that is relevant to AAN interests or activities.

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