Abstract Details

Title Identifying Neural Activity Related to Both How and Why Movements are Performed

Topic Aging, Dementia, and Behavioral Neurology

Presentation(s) P1 - Poster Session 1 (5:30 PM-6:30 PM)

Poster/Presentation
Number 9-028

Objective To identify where neural activity encodes instructional information and movement information using electroencephalography (EEG).

Background Neural activity in motor cortical areas has been shown to encode specific hand and arm movements. Motor cortex integrates sensory information to perform movements. Whether the same movements performed using different sensory information changes motor cortex activity is less understood. Behavioral tasks involving voluntary movements often use a single instruction paradigm. Understanding the role that different instruction modalities play in modulating motor cortical activity is important to identify neural pathways involved in performing voluntary movements.

Design/Methods Fourteen healthy human participants performed an object-manipulation task in which different objects were instructed using either visual or auditory instructions containing information about the target object’s identity or how it is used. During the task, neural activity was recorded using EEG. Event-related potentials (ERPs) were measured from each participant, averaged across participants, and aligned on the time on hand movement. Separate ERPs were computed for trials involving each of the different instruction types and each of the different target objects.

Results Each participant was able to use the different instructions to perform the associated movements. Across participants, electrodes located on the frontal, contralateral side demonstrated distinct ERP waveforms differentiating both the sensory modality of the instruction (p<0.001) and the target object (p<0.001). Thus, ERPs were able to distinguish both the action performed and the instruction used to perform that action in the same electrode location.

Conclusions We identified neural activity recorded from the same location that differentiated the instruction delivered and the movement performed. Future work will identify whether neural activity changes in the presence of a focal injury damaging processing of either sensory instruction. Such study will aid in the development of therapeutic solutions that utilize intact neural pathways for rehabilitating function.

Authors/Disclosures
Kevin A. Mazurek, PhD (Mayo Clinic) PRESENTER	Dr. Mazurek has received personal compensation for serving as an employee of Delos Living / Well Living Lab. Dr. Mazurek has received intellectual property interests from a discovery or technology relating to health care. An immediate family member of Dr. Mazurek has a non-compensated relationship as a Editor with AAN Resident and Fellows Section that is relevant to AAN interests or activities.
David P. Richardson	No disclosure on file
	No disclosure on file
	No disclosure on file
	No disclosure on file

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