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Abstract Details

Degree of Retinal Nerve Fiber Layer Thinning in Pediatric MOG-associated Optic Neuritis Appears Similar to Pediatric NMO
Autoimmune Neurology
P1 - Poster Session 1 (5:30 PM-6:30 PM)
15-002
To compare the degree of optic atrophy in optic neuritis (ON) that occurs in the setting of anti-MOG (myelin oligodendrocyte glycoprotein) antibodies with ON that occurs in pediatric-onset multiple sclerosis (POMS-ON) and pediatric neuromyelitis optica (NMO-ON) as measured by the thickness of the retinal nerve fiber layer (RNFL) on optical coherence tomography (OCT). 

MOG antibodies are associated with bilateral ON and relapsing ON. However, there is limited data regarding the degree of resulting optic atrophy.

Charts of all MOG+, POMS, and NMO patients at Texas Children’s Hospital between 2010-2018 with a history of ON were reviewed. Inclusion criteria consisted of having OCT performed at least 2 months after the first episode of ON.

 

RNFL values for all eyes affected by ON were obtained.

 

Independent sample t-tests were conducted to compare RNFL values for the MOG+, POMS, and NMO ON-eyes.

The mean age at first attack of the 10 MOG+ patients was 8.8 years (6-13) with a mean disease duration of 28.4 months (2-84).  The MOG antibody titer level ranged from 1:20-1:1000.

 

The mean age of diagnosis of the 10 POMS patients was 13.9 years (10-17) with a mean disease duration of 63.5 months (40-132). 

 

The mean age of diagnosis of the 4 NMO patients was 11.6 years (4-16) with a mean disease duration of 54 months (40-91).

 

There was no significant difference in the RNFL thickness for MOG+ ON (n=11, mean=62.2, SD=22) and NMO-ON (n=6, mean=46.6, SD=4.3); t=1.59, p=0.06.

 

There was a significant difference in the RNFL thickness for MOG+ ON (mean=46.6, SD=22) and MS-ON (n=12, mean=77.5, SD=15); t=1.82, p=0.04.

 

There was a significant difference in the RNFL thickness for NMO-ON and MS-ON; t=4.46, p=0.0002.

 

Though limited by the small number of patients, our data suggests that MOG-related ON causes a similar degree of optic atrophy as NMO-ON and more severe optic atrophy compared to POMS-ON.  
Authors/Disclosures
Nikita Shukla, MD (BCM)
PRESENTER 		The institution of Dr. Shukla has received research support from Roche.
No disclosure on file
Timothy E. Lotze, MD, FAAN (Texas Children's Hospital) Dr. Lotze has received personal compensation in the range of $5,000-$9,999 for serving as an Expert Witness for Department of Justice VICP. The institution of Dr. Lotze has received research support from NIH. The institution of Dr. Lotze has received research support from National MS Society. The institution of Dr. Lotze has received research support from Sarepta Therapeutics. The institution of Dr. Lotze has received research support from PTC THERAPEUTICS. The institution of Dr. Lotze has received research support from Avexis. Dr. Lotze has received publishing royalties from a publication relating to health care. Dr. Lotze has received publishing royalties from a publication relating to health care.