Abstract Details

Title Spectral-Domain Optical Coherence Tomography in Autoimmune Disorders with Optic Neuropathy: A Retrospective Analysis of Distinctive Features.

Topic Autoimmune Neurology

Presentation(s) P1 - Poster Session 1 (5:30 PM-6:30 PM)

Poster/Presentation
Number 15-014

Objective To assess the distinctive features of retinal structure in autoimmune disorders with optic neuropathy; Chronic relapsing inflammatory optic neuropathy (CRION), Neuromyelitis optica (NMO), Relapsing remitting multiple sclerosis (RRMS) and Neurosarcoidosis (NS).

Background Optical coherence tomography (OCT) is a non-invasive high-resolution imaging technique that has facilitated characterization of retinal alterations in patients with optic neuritis and its distinctive role in differentiating autoimmune disorders is under study.

Design/Methods Spectral domain OCT was used to evaluate and compare the retinal layers of fifty-three eyes with optic neuritis in patients with CRION (10 eyes), NMO (9 eyes), RRMS (14 eyes), NS (10 eyes) and 10 eyes of healthy controls (HC). The groups were matched for age, disease duration and number of relapses. Peripapillary retinal nerve fiber layer (p RNFL) within superior, inferior, temporal, nasal and total macular volume (TMV) and papillomacular bundle (PMB) were measured and intra-retinal segmentation was performed to obtain retinal nerve fiber (RNFL), ganglion cell (GCL), inner plexiform (IPL), inner nuclear (INL), outer plexiform (OPL) and outer nuclear (ONL) layer thickness.

Results pRNFL thinning was demonstrated in patients with CRION (42±9.6µm) as compared to HC (92.3±10.9µm, P-value<0.0005), RRMS (75.5±14.6µm, P-value<0.0005), NS (84.1±21.2µm, P-value<0.0005) and NMO patients (66.5±5.3µm, P-value=0.019). pRNFL was also significantly thinner in NMO patients as compared to HC (P-value=0.012). RNFL volume in macula was lower in CRION patients (0.46±0.09mm³) when compared to HC (0.91±0.12mm³, P-value<0.0005), RRMS(0.68±0.15mm³, P-value=0.002) and NS(0.77±0.09mm³ P-value<0.0005), however it did not reach significance with NMO group(0.59±0.16mm³, P-value=0.33). NS patients did not also show any significant difference with HC in RNFL volume (P-value=0.206).

Conclusions pRNFL thickness and macular volumes could be used as surrogates to differentiate CRION from optic neuropathy associated with other autoimmune disorders, in particular RRMS. Further longitudinal studies are warranted to confirm these findings.

Authors/Disclosures
Shitiz K. Sriwastava, MBBS (UT Health Houston) PRESENTER	Dr. Sriwastava has nothing to disclose.
Sara Razmjou-Schwarz, MD (Mclaren Macomb hospital)	No disclosure on file
Samuel Lichtman-Mikol, BA (Wayne State University)	Mr. Lichtman-Mikol has nothing to disclose.
Maziar Eslami, MD (The Neurology group)	Dr. Eslami has nothing to disclose.
Melody Gilroy, BS	Ms. Gilroy has nothing to disclose.
Evanthia Bernitsas, MD, FAAN (Wayne State School of Medicine)	Dr. Bernitsas has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Amgen. Dr. Bernitsas has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Vanda. The institution of Dr. Bernitsas has received research support from Roche/Genentech.

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