Abstract Details

Title Neuromyelitis optica spectrum disorders: The evaluation of 66 patients followed by Istanbul Bilim University, Department of Neurology

Topic Multiple Sclerosis

Presentation(s) P1 - Poster Session 1 (5:30 PM-6:30 PM)

Poster/Presentation
Number 15-075

Objective Neuromyelitis optica spectrum disorders (NMOSD) are relatively rare disorders when compared to multiple sclerosis (MS).

Background We aimed to evaluate clinical characteristics and disease course of the NMOSD patients followed at our department.

Design/Methods All the patients with the diagnosis of NMOSD according to the Wingerchuck diagnostic criteria 2015 followed since the establishment of our MS clinic in April 2011, were evaluated.

Results There were 66 patients (51 female, 15 male) with NMOSD followed at our MS unit. The mean age of the patients was 44,1±16,8 (17-84) years. The mean age of the patients on disease onset is 32.5± 16.9 (11-82) years. The disease duration was 8.1±6.5 years. The disease course was relapsing in 55 patients (83%). The attacks were triggered by infection in 2 patients and by vaccines in 3 patients. The first attack was optic neuritis (ON) and transverse myelitis (TM) in 12 patients (6 patients had bilateral ON (BON)), TM and area postrema syndrome (APS) in 4 patients (2 patients had also ON; one had BON and the other had ON), ON in 30 patients (BON in 5), TM in 17 patients (1 patient had also diencephalic syndrome), APS in 3 patients. The mean EDSS score was 3.5±2.1(1-8) at the last visit. NMO IgG was positive in 43 patients (65%). MOG was evaluated in 17 out of 66 patients and were all negative. Oligoclonal band was positive in 13 out of 33 patients (39%). In NMOSD patients, cranial magnetic resonance imaging (MRI) showed no abnormality in 31; nonspecific lesions in 22; chiasmal lesion in 1, brainstem lesions in 5, large hemispheric lesion in 2 and hypothalamic lesion in 1 patient. In spinal MRIs, 43 patients had longitudinally extensive transvers myelitis (LETM); 12 had short segment TM (STM) and in 11 patients it was normal.

Conclusions This is one of the largest single center series collected over 7 years. NMOSD seems to be over-represented in our center since it is one of the few where NMO IgG/MOG testing is available. In NMOSD, early diagnosis and treatment, as well as differentiation from MS, is important to prevent the patient from the permanent disability.

Authors/Disclosures
Burcu Altunrende, MD (Istanbul Bilim University - Dept of Neurology) PRESENTER	No disclosure on file
	No disclosure on file
	No disclosure on file
Firedevs Gulsen A. Demir, MD, PharmD (Istanbul Florence Nightingale Hastanesi)	Dr. Demir has nothing to disclose.

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