Flaccid paralysis developed from the tip of the tail at day 11–13 p.i. in both αT-treated and non-treated control rats. The latter gradually progressed to flaccid paraplegia, and then reached a peak of motor impairment on day 16 p.i. followed by spontaneous recovery. Double administration of αT significantly improved the clinical course, decreased the level of the lipid peroxidic marker N epsilon-(hexanoyl) lysine, and suppressed the mRNA expression of interferon-gamma and interleukin-10 in the popliteal lymph nodes and cauda equina. Histologically, αT treatment reduced demyelination in the cauda equinacompared to that of control rats. However, single administration of αT was not sufficient to produce these effects.