Abstract Details

Title Oxidized Albumin in Acute Ischemic Stroke is Associated With Better Outcomes

Topic Autoimmune Neurology

Presentation(s) P1 - Poster Session 1 (5:30 PM-6:30 PM)

Poster/Presentation
Number 15-092

Objective To examine the relationship of admission oxidized human serum albumin (OxHSA) and CXCL-10 with favorable mRS in acute ischemic stroke (AIS).

Background Oxidative stress and inflammation are present in AIS. OxHSA is evidence of an active antioxidant mechanism as measured by oxidized species of HSA. CXCL-10 is a pro-inflammatory chemokine associated with ischemic conditions.

Design/Methods A convenience sample of AIS patients was obtained at a Comprehensive Stroke Center (2010-2011). Plasma samples were collected prospectively and clinical data were obtained. Admission biomarkers of oxidative stress, CXCL-10 and %OxHSA, were measured from the plasma samples. We examined whether CXCL-10 or %OxHSA were correlated with age, admission NIHSS score, and discharge mRS score using Spearman’s Rank correlation. Logistic regression was performed to identify independent predictors of a favorable discharge mRS (≤2).

Results In 106 AIS patients, the median age was 73 (IQR 61-84), 47% were male, and the median admission NIHSS score was 11 (IQR 5-19). %OxHSA and CXCL-10 were significantly correlated (r=0.23, p=0.02). Both biomarkers were significantly correlated with age: %OxHSA (r=0.44, p<0.001) and CXCL-10 (r=0.32, p=0.001). Neither biomarker was correlated with admission NIHSS. There was a borderline significant correlation with the discharge mRS and %OxHSA (r=-0.17, p=0.08), where higher %OxHSA was correlated with lower mRS scores (better outcomes). For every 1% increase in %OxHSA, the odds of a favorable discharge mRS increased 11%. The odds of a favorable discharge mRS decreased 18% for every 1 point increase in the initial NIHSS.

Conclusions Oxidative stress and inflammation occur in AIS. OxHSA, the result of an oxidative environment and evidence of the strong antioxidant buffering capacity of HSA, correlated with CXCL-10 and discharge mRS, implying that strong antioxidant activity of albumin confers better outcomes.

Authors/Disclosures
Kristin Salottolo, MPH PRESENTER	Ms. Salottolo has nothing to disclose.
	No disclosure on file
Jan Leonard	No disclosure on file
Russell E. Bartt, MD, FAAN (Blue Sky Neurosciences)	Dr. Bartt has nothing to disclose.
Jeffrey C. Wagner, MD (Carepoint HC)	Dr. Wagner has nothing to disclose.
David Bar-Or	David Bar-Or has received intellectual property interests from a discovery or technology relating to health care.

��ɫ��

��ɫ��