Abstract Details

Title Outcome of mechanical thrombectomy in patients with acute ischemic stroke on anticoagulation therapy

Topic Cerebrovascular Disease and Interventional Neurology

Presentation(s) P1 - Poster Session 1 (5:30 PM-6:30 PM)

Poster/Presentation
Number 3-014

Objective N/A

Background The clinical benefit of mechanical thrombectomy (MT) for treatment of Acute Ischemic Stroke (AIS) has been demonstrated in several recent trials; however, its safety and efficacy in patients on anticoagulation (AC) is not well understood. Here, we examine the clinical and angiographic outcomes of AIS patients on anticoagulation therapy who were treated with MT

Design/Methods A retrospective review of our prospective MT database was performed for this study. Baseline characteristics, National Institutes of Health Stroke Scale (NIHSS) score, revascularization rate, 90-day mortality and favorable outcome (modified Rankin scale (mRS) score 0-2) were compared with AIS patients on therapeutic AC (AC+) versus those not on AC (AC-)

Results From January 2015 to July 2018, 276 AIS patients underwent treatment with MT, with 31 patients on AC. No difference was observed in median age (74 versus 77), female gender (53.1% versus 61.3%), median NIHSS (17 versus 17), hypertension (82.9% versus 83.4%), and hyperlipidemia (64.5% versus 56.7%) between the AC+ and AC- groups, respectively; a higher rate of atrial fibrillation was present in the AC+ cohort (83.9% versus 44.5%, p=<0.0001). The MCA was the most common site of occlusion, with 67.2% and 74.2% in the AC- and AC+ cohorts, respectively. Successful revascularization (TICI≥2b) rates were similar between the groups (81.2% AC- versus 86.7% AC+). No difference was seen in the rates of favorable outcome (42.3% versus 50.0%) and morality (25.0% versus 30.0%) in the AC- and AC+ groups, respectively.

Conclusions Our study demonstrated a similar safety and clinical outcome profile in AIS patients on AC who underwent MT. Further studies, including randomized clinical trials, are needed to confirm these findings

Authors/Disclosures
Nurose Karim, MD (ECU Health Medical Center) PRESENTER	Dr. Karim has nothing to disclose.
Alicia C. Castonguay, PhD	Dr. Castonguay has nothing to disclose.
Ehad Afreen, MD (Promedica Physicians Group Neurology)	Dr. Afreen has nothing to disclose.
Hisham Salahuddin, MD	Dr. Salahuddin has nothing to disclose.
Syed F. Zaidi, MD (ProMedica Stroke Network)	Dr. Zaidi has nothing to disclose.
Mouhammad A. Jumaa, MD (ProMedica Stroke Network)	Dr. Jumaa has nothing to disclose.
Julie Shawver (Promedica Physicians Group)	No disclosure on file

��ɫ��

��ɫ��