Abstract Details

Title Hyperviscosity in Acute Ischemic Stroke with Large Vessel Steno-occlusive Lesion

Topic Cerebrovascular Disease and Interventional Neurology

Presentation(s) P1 - Poster Session 1 (5:30 PM-6:30 PM)

Poster/Presentation
Number 3-051

Objective

We aimed to find whether hyperviscosity has an association in larger artery disease according to lesion pattern and distribution.

Background Elevated blood viscosity, which is one of the parameters that determine blood rheology, has been reported as a risk factor for cerebrovascular events. Some authors suggested hyperviscosity is associated with stroke patients with small vessel disease or atrial fibrillation. However, hyperviscosity in large artery stroke still remains uncertain.

Design/Methods From January 2017 to December 2017, we retrospectively reviewed patient record consecutively admitted to our stroke clinic with acute infarction with large artery disease. Patients confirmed to have larger artery stroke according to TOAST classification and performed blood viscosity study were selected. Whole blood viscosities measured at a high or low rate using a scanning capillary tube viscometer were referred as systolic blood viscosity (SBV) and diastolic blood viscosity (DBV), respectively. Correlations between blood viscosity and large artery stroke patients according to lesion pattern (stenosis or occlusion) and lesion distribution (anterior or posterior circulation territory).

Results

A total of 154 patients were enrolled. Of the 154 patients (mean age 68.07±12.61 years), 107 (69.5%) were male. Large artery diseases were involved in intracerebral artery (n=52, 33.8%), middle cerebral artery (n=58, 37.7%), anterior cerebral artery (n=4, 2.6%), posterior cerebral artery (n=8, 5.2%) and vertebrobasilar artery (n=32, 20.8%), respectively. Of them 101 vessels were stenotic (65.5%) and remaining 53 vessels (34.4%) were occluded. Although there was any correlation between lesion distribution and blood viscosity, SBV was significantly higher in patients with occlusive lesion than those with stenotic lesion (p=0.045) and DBV showed slightly increased in former without statistical significance (p=0.061).

Conclusions

Hyperviscosity in high blood flow state in larger artery occlusive stroke patients is elevated than in those with stenotic lesion. This might suggest hemorheological differences in larger artery stroke patients according to the lesion pattern.

Authors/Disclosures
Si Baek Lee PRESENTER	Si Baek Lee, 1512 has nothing to disclose.
	No disclosure on file
	No disclosure on file
	No disclosure on file
	No disclosure on file

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