Abstract Details

Title Time-Domain Near Infrared Spectroscopy in Acute Ischemic Stroke Patients with Different Sites of Large Vessel Occlusion.

Topic Cerebrovascular Disease and Interventional Neurology

Presentation(s) P1 - Poster Session 1 (5:30 PM-6:30 PM)

Poster/Presentation
Number 3-052

Objective

To evaluate if Time-Domain Near-Infrared spectroscopy (TD-NIRS) could to detect differences of microcirculation's oxygenation among acute ischemic stroke patients (AIS) with different sites of large vessel occlusion (LVO) and mild clinical severity.

Background Steno-occlusive disease of LVO might cause different degrees of hemodynamic impairment in AIS that can lead to different hemodynamic and metabolic effects on cerebral microcirculation.

Design/Methods We enrolled AIS patients due to ICA or MCA LVO documented on CTA/MRA, with NIHSS ≤10. Patients were classified as ICA group (ipsilateral ICA LVO), or MCA group (MCA LVO). As comparator we used a cohort of 56 healthy subjects ≥55 y. Collaterals were assessed using CT/MR-based grading systems. TD-NIRS measurements were performed on multiple brain regions during the sub-acute phase of stroke. Fiducial markers categorized the brain region below each TD-NIRS probe as ischemic area (IA), non-stroke areas of ipsilateral (NSI) and contralateral hemisphere (NSC).

Results The ICA group included 4 patients (age 69.7±12.7) with median (IQR) NIHSS 3.5 (2.5-6.2). The circle of Willis was incomplete. Leptomeningeal collaterals were graded as intermediate. The MCA group included 2 patients (age 69.5±2.1) with median (IQR) NIHSS 5 (3-7). MCA patients had preserved circle of Wills and good leptomeningeal collaterals. ICA patients had lower StO₂ compared to controls in all probed areas (IA 49.2%, NSI 45.6%, NSC 47% vs. 57.8%, p=1.6 10^-4; p=1 10^-6, p=5 10^-6). In addition, NSI and NSC had lower oxyhemoglobin compared to controls (19.8 μM, 22.3 μM vs. 31.2 μM; p=0.005, p=0.043). ICA patients had lower StO₂ compared to MCA patients (IA 49.2% vs. 59.9%, p=0.011; NSI 45.6% vs. 60.4%, p=0.001; NSC 47% vs. 58.6%, p=0.039).

Conclusions Despite similar clinical severity, only ICA patients had lower StO₂ compared to controls. In addition, ICA patients had lower StO₂ compared to MCA patients. These findings suggest that StO₂ might discern different degrees of hemodynamic impairment.

Authors/Disclosures
PRESENTER	No disclosure on file
	No disclosure on file
	No disclosure on file
	No disclosure on file
	No disclosure on file
	No disclosure on file
	No disclosure on file

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