Abstract Details

Title Relationship between Forced Vital Capacity and Slow Vital Capacity in individuals with Amyotrophic Lateral Sclerosis Patients

Topic Neuromuscular and Clinical Neurophysiology (EMG)

Presentation(s) P1 - Poster Session 1 (5:30 PM-6:30 PM)

Poster/Presentation
Number 12-011

Objective

To compare progression of both the forced vital capacity maneuver (FVC) and the slow vital capacity maneuver (VC) of Amyotrophic Lateral Sclerosis (ALS).

To determine whether the VC maneuver is as consistent a measure of respiratory muscle decline as the FVC maneuver.

Background The FVC is the amount of air a person can forcibly exhale in one breath. The VC is the volume of air mobilized between a maximal inspiratory maneuver and a maximal expiratory maneuver. The FVC maneuver has been used in medical research to record the decline in respiratory muscle strength in neuromuscular disease. Many other respiratory parameters are also used for this purpose, like the to collapse vital capacity. Information is needed to see if the VC is a reliable measurement tool.

Design/Methods A retrospective review was conducted on ALS patient's at The Ohio State University Wexner Medical Center from February 2016 - June 2017. Repeated measures of FVC and VC were collected longitudinally and reported as the average value for each patient. Patient demographics and clinical data were summarized with descriptive statistics. Pearson correlation analysis was used to assess the association between the first observed measures of FVC and VC.

Results There were 75 patients included in this analysis with mean (std) age of 60.6 (11.5) years. The mean (std) values of FVC and VC for each patient were 2.2 (1.1) and 1.8 (0.9), respectively. The first observed FVC per patient was strongly correlated with the corresponding VC value (r=0.8872, p value <0.0001). The average percent decrease over time for FVC was 23% and the average percent decrease for VC was 19.7%.19%.

Conclusions The FVC is not always the best way to measure air volume. Upper airway muscles can weaken in ALS potentially causing airway collapse. VC is not forced , less likely to cause airway collapse. VC proved safe and reliable.

Authors/Disclosures
Jerold E. Reynolds, PhD, RCP, RRT (CarePoint East) PRESENTER	Dr. Reynolds has nothing to disclose.

��ɫ��

��ɫ��