Abstract Details

Title Lifetime Sport Practice and Brain Metabolism in Amyotrophic Lateral Sclerosis: a 18F-FDG-PET study

Topic Neuromuscular and Clinical Neurophysiology (EMG)

Presentation(s) P1 - Poster Session 1 (5:30 PM-6:30 PM)

Poster/Presentation
Number 12-028

Objective The aim of the present study was to evaluate the relationship between the practice of sport activities during life and brain metabolism assessed by ¹⁸F-FDG-PET at ALS diagnosis.

Background The impact of physical activity on the risk of Amyotrophic Lateral Sclerosis (ALS) has been investigated in several studies with controversial results.

Design/Methods We enrolled 131 ALS patients at the ALS Centre of Turin, Italy. Lifetime sport practice was assessed through a structured questionnaire in the context of the Euromotor Project. A quantitative measure of sport practice was then obtained through the transformation into Metabolic Equivalents of Task (MET). Brain metabolism was assessed by ¹⁸F-FDG-PET. We classified patients as: NO sport practice (N, i.e. 0 MET), YES sport practice (Y, i.e. >0 MET), first tertile of the Y group (T1), third tertile of the Y group (T3). We used the two-sample t-test model of SPM12 to compare patients belonging to different groups. We considered age at PET, sex, spinal/bulbar onset, and total ALS FRS-R score as covariates.

Results

In the comparison between the N group and the Y group we identified a relative hypermetabolism in the N group in the cerebellum bilaterally (p<0.005_uncorrected). A relative bilateral cerebellar hypermetabolism was also found in the N group compared to the T1 group(p<0.005_uncorrected).

Conclusions

Patients who never practiced sport showed a relative hypermetabolism compared to patients who did. A similar difference was detected between patients who never practiced sport and patients who practiced light sport activity. No difference was found between patients who never practiced sport and patients who practiced intense sport activity. According to our results, sport practice has a different impact based on the different intensity of physical activity, without a dose-dependent behavior.

Authors/Disclosures
Cristina Moglia (University of Torino) PRESENTER	Cristina Moglia has nothing to disclose.
Antonio Canosa	Antonio Canosa has nothing to disclose.
Andrea Calvo, MD, PhD, FAAN (Dept. of Neuroscience, University of Turin)	Dr. Calvo has nothing to disclose.
Federico Casale	No disclosure on file
	No disclosure on file
	No disclosure on file
Adriano Chio, MD, FAAN (Dept. of Neuroscience, University of Turin)	Dr. Chio has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Cytokinetics. Dr. Chio has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Mitsubishi. Dr. Chio has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Biogen. Dr. Chio has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Corcept.

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