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Abstract Details

Characterizing Peri-Ictal Mood Changes in Patients with Epilepsy
Epilepsy/Clinical Neurophysiology (EEG)
P1 - Poster Session 1 (5:30 PM-6:30 PM)
6-002
To quantitatively analyze peri-ictal mood changes in seizure patients admitted to the inpatient Epilepsy Monitoring Unit (EMU) at the University of Maryland Medical Center. 
Epilepsy is a chronic neurological disorder that affects 50 million individuals worldwide. Up to 40-60% of patients with epilepsy report feeling depressed, and rates of suicide are ten times higher in patients with epilepsy compared to the general population. While past studies have demonstrated a correlation between depressive symptoms and seizure type, mood fluctuations are less well characterized in the peri-ictal period, which is defined as the hours before and after a seizure.
We enrolled patients admitted to the EMU for continuous video electroencephalography monitoring (VEM). Patients completed three validated mood questionnaires (Beck Depression Inventory-II, Beck Anxiety Inventory, and Montgomery Asberg Depression Rating Scale) at enrollment and at four intervals following a seizure event: 4 hours, 12 hours, 24 hours, and 2 weeks. The EEG was interpreted by a board-certified epileptologist to determine whether the patient had epileptic seizures or psychogenic nonepileptic seizures, and to classify (focal or generalized) and localize the epileptic seizures.
Of the 123 patients who enrolled in the study and were eligible to participate, 33 patients had epileptic seizures and 27 patients had nonepileptic seizures. Mood scores improved in the 24 hours following an epileptic seizure (BDI: -5.56, p=0.017; MADRS: -4.57, p=0.012) but returned to baseline after 2 weeks. Furthermore, there was a greater improvement in depression and anxiety scores in patients with focal-onset epilepsy (BDI: -7.37, p=0.022; BAI: -4.44, p=0.013; MADRS: -5.16, p=0.018) versus generalized onset.
Patients experienced a statistically significant but transient improvement in mood following a seizure event. Focal-onset seizures were more strongly correlated with mood improvement compared to generalized seizures.
Authors/Disclosures
Autusa Pahlavan, BS
PRESENTER 		No disclosure on file
No disclosure on file
Jennifer L. Hopp, MD, FAAN (University of Maryland Medical System) The institution of Dr. Hopp has received research support from MII TA Grant 20180828 TEDCO EpiWatch: A Mobile Health Application for Epilepsy Management. The institution of Dr. Hopp has received research support from MII TA Grant TEDCO Project #0723-012 EPIScalp; A Novel Tool for Diagnosing Epilepsy from Scalp EEG. The institution of Dr. Hopp has received research support from NIH R44NS137845. Dr. Hopp has received publishing royalties from a publication relating to health care. Dr. Hopp has received personal compensation in the range of $5,000-$9,999 for serving as a Faculty with J. Kiffin Penry Epilepsy 好色先生al Programs.