Abstract Details

Title Tumors in the cauda equina: a SEER analysis of tumor types and predictors of outcome

Topic Neuro-oncology

Presentation(s) P1 - Poster Session 1 (5:30 PM-6:30 PM)

Poster/Presentation
Number 7-001

Objective

Using SEER data, we analyzed the demographic features, tumor types, treatment and survival of primary cauda equina tumors.

Background Cauda equina tumors are histologically diverse. Cauda equina has a dedicated site code (C72. 1) in the International Classification of Diseases for Oncology (ICD-O3) and is often excluded during analyses of primary spinal cord tumors. Therefore, less is known about tumors in this location.

Design/Methods SEER data from 1997 to 2015 were reviewed for primary cauda equina tumors (C72. 1) excluding the tumors of spinal meninges (C70. 1). We describe demographics, tumor types and compare these with clinical outcome using univariate analysis. Treatment and survival analysis was performed using Kaplan-Meier curves.

Results Ninety-two patients with primary cauda equina tumors met the inclusion criteria. These tumors comprised ependymoma (73%), glioblastoma (5%), lymphoma (5%), ewing sarcoma (3%) and solitary occurrences of neurilemmoma, fibrosarcoma, germinoma, teratoma. The median age at diagnosis was 49 years (<1 year and 98 years), 55% were males, predominantly white (87%). Eighty percent of the patients received surgery. Median follow up time was 102. 5 months. Of 92 patients, 68 (73%) are still alive. The cause of death is tumor or CNS related in 58% of patients. Of the 92 patients, 62(67. 4%) survived more than 5 years and 19 (20. 7%) died before 5 years. 11 patients (12. 0%) were censored before 5 years. Using univariate analysis, age at diagnosis was independent predictor of increased tumor specific mortality (HR1. 03, CI 1. 01-1. 06), while non-ependymal tumor type (HR 0. 14, CI 0. 06- 0. 33) and surgical intervention (HR 0. 18, CI 0. 08- 0. 40) were independent predictors of improved survival (p<0. 001 for each).

Conclusions Cauda equina tumors are predominantly ependymal in origin. Although most patients do well, older age and lack of surgical intervention are associated with worse survival.

Authors/Disclosures
Saurav Das, MD (Washington University in St. Louis) PRESENTER	Dr. Das has nothing to disclose.
Alex Urevick	No disclosure on file
	No disclosure on file
Eric C. Burton, MD (National Institute of Health)	No disclosure on file

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