Abstract Details

Title Incidence of Distant Recurrence in Adult Gliomas

Topic Neuro-oncology

Presentation(s) P1 - Poster Session 1 (5:30 PM-6:30 PM)

Poster/Presentation
Number 7-006

Objective Estimate the incidence of distant (first) recurrence (more than 2 cm from original tumor site) in adult gliomas, and assess incidence variation by histology.

Background CT-based analyses in the 1980's estimated 78-90% rate of local recurrence in glioblastoma, and informs present practice of radiotherapy to a 2-3 cm treatment margin around clinical treatment volume. We sought to confirm this observation in the MRI-era.

Design/Methods We retrospectively determined enhancing or non-enhancing recurrence pattern (local or distant >2cm from original site) in WHO grade II-IV gliomas by RANO. We also explored whether histology, IDH-mutation or tumor location predicted recurrence pattern. Patients with pseudoprogression (stability or improvement on subsequent imaging before treatment change) were excluded.

Results There were 72 patients (54% men, 46% women; median age 58 years at diagnosis, range 24-85). Histology was glioblastoma (WHO grade IV) in most (63, 88% including 3 with gliosarcoma), 4 anaplastic (WHO grade III), and 4 low grade (WHO grade II). Among all 72 patients, distant relapse was observed in 21%. IDH mutation was rare (8%), and frequency did not differ by recurrence pattern. Distant relapse occurred in 23% when initial enhancing tumor involved both cortex and ventricle (31, 43% of tumors), and 17% when neither was involved (6, 8% of tumors). Of note, there were 4 low grade tumors and 3 recurred locally.

Conclusions Distant relapse (>2cm from original tumor) occurred in 21% of gliomas and was more common when tumor originally involved both cortex and ventricle. IDH mutation was too infrequent and there were too few grade II-III tumors to assess correlations.

Authors/Disclosures
Peter C. Pan, MD (Columbia NYP) PRESENTER	No disclosure on file
	No disclosure on file
Fabio M. Iwamoto, MD	No disclosure on file
Teri Kreisl (Neuro-oncology Branch, National Cancer)	No disclosure on file
Mary Welch, MD (Columbia University Medical Center)	Dr. Welch has nothing to disclose.
Aya M. Haggiagi, MD (Columbia University Medical Center)	No disclosure on file
	No disclosure on file
Andrew B. Lassman, MD, FAAN (Columbia University Irving Medical Center)	No disclosure on file

��ɫ��

��ɫ��