Abstract Details

Title Children with Neurogenetic Disorders Hospitalized with Community-acquired Pneumonia are at Increased Risk for Poor Outcomes

Topic Child Neurology and Developmental Neurology

Presentation(s) P1 - Poster Session 1 (5:30 PM-6:30 PM)

Poster/Presentation
Number 7-042

Objective

The objectives of this study were to list the most common neurogenetic disorders in pediatric patients hospitalized with CAP, and to compare clinical outcomes for patients with and without neurogenetic disorders.

Background

Pediatric patients with neurogenetic disorders are at risk for multiple infections. There is limited data on the burden of community acquired pneumonia (CAP) and outcomes in the pediatric population with neurogenetic disorders.

Design/Methods This was a retrospective cohort study of children aged 1 month to 18 years hospitalized with CAP at Norton Children's Hospital in Louisville during a 6 month period. Clinical outcomes compared for patients with and without neurogenetic disorders were time to clinical stability (TCS) and length of hospital stay (LOS). Categorical variables were compared using chi-square tests and continuous variables were compared using Mann-Whitney U tests. P-values less than 0.05 were considered significant.

Results From a total of 126 pediatric patients hospitalized with CAP, the presence of neurogenetic disorders were identified in 18 (14%) patients. The list of neurogenetic disorders identified were as follows: Aicardi syndrome, Doose syndrome, Dravet syndrome, Lennox-gestuat syndrome, Myotonic Dystrophy, Noonan syndrome, Pallister-Killian syndrome, Spinal muscular atrophy, Trisomy 18, and VATER syndrome. The median time to clinical stability for patients with neurogenetic disorders was 4 days (IQR: 2-8) compared to 2 days (IQR: 2-3) in patients without neurogenetic disorders (p=0.027). The median length of stay was 10 days (IQR: 4-17) for neurogenetic disorder patients as opposed to 4 days (IQR: 2-5) for those without neurogenetic disorders (p=0.002).

Conclusions

Patients with neurogenetic disorders have prolonged time to reach clinical improvement and longer duration of hospital stay. Since an association exists between neurogenetic disorders and lung development, a better understanding of the pathophysiology of pneumonia in these patients is necessary. Prevention of pneumonia in this vulnerable population is essential.

Authors/Disclosures
Murali K. Kolikonda, MD (Baptist of Lexington) PRESENTER	No disclosure on file
Rajashekar Reddy Yeruva, MBBS	No disclosure on file
	No disclosure on file
	No disclosure on file

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