Abstract Details

Title Early Experiences with Multiple Independent Current Control DBS in Parkinson’s Disease

Topic Movement Disorders

Presentation(s) P1 - Poster Session 1 (5:30 PM-6:30 PM)

Poster/Presentation
Number 10-034

Objective To evaluate retrospectively the early effects of Deep Brain Stimulation using Multiple Independent Current Control stimulation (MICC DBS) on patients with Parkinson’s disease (PD) in a single center.

Background Deep Brain Stimulation is effective for treatment of Parkinson’s disease patients with motor fluctuations that are not well controlled. INTREPID trial, an ongoing randomized double blind RCT of multiple source constant current rechargeable system demonstrated an improvement of 49.2% in the UPDRS scores and a 6 hour improvement in the ON time without troublesome dyskinesia (Vitek 2018).

Design/Methods A retrospective review was performed on patients who underwent MICC DBS for PD from August 2016 to March 2018. Only patients who had follow up for six months with regular DBS programming were included in the review. A minimum of 2 programming sessions was required within the first 6 months. The outcome measures included Levodopa Equivalent daily dose (LEDD), Unified Parkinson’s Disease Rating Scale (UPDRS), and dyskinesia experienced.

Results In total 9 patients were included in the study. UPDRS of meds off DBS was 41.25 , on meds off= 15.25. At 6 months after DBS motor scores improved 59%( UPDRS OFF MEDS ON DBS =17+/- 7 , UPDRS ON MEDS, ON DBS= 8.7+/-5 ). 8 patients are currently using multiple contacts for field shaping and 1 patient was using one contact. 2 patients were completely off of their levodopa medications following MICC DBS surgery. The overall reduction in levodopa was 52%. Only one patient reported experiencing dyskinesia following surgery.

Conclusions

Multiple Independent Current Control DBS in Parkinson’s disease significantly improves the motor scores and reduces the LEDD.

Authors/Disclosures
Daniel R. Lorido PRESENTER	No disclosure on file
Jonathan Jagid	Jonathan Jagid has received personal compensation in the range of $10,000-$49,999 for serving as an Expert Witness for Miami Dade County State Attorneys office. The institution of Jonathan Jagid has received research support from Boston Scientific.
Corneliu C. Luca, MD (University of Miami)	Dr. Luca has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Boston Scientific. Dr. Luca has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Signant Health. Dr. Luca has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Abbott.

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