The pupillary light reflex is an important component of the neurological exam. Quantitative pupillometry may offer advantages over the qualitative clinical exam. Commercially available devices are cumbersome, require operator expertise, or are not customizable.

For control subjects the pupil response curves for different intensities and duration of blue light stimuli were similar to those reported by Park et al. Curves for 3 min dark adaptation were similar to 10 min dark adaptation. In the control subject maximum constriction PIPR were 65.5%, 47.1% in the left eye and 69%, 31.1% in the right eye following a bright blue stimulus. For the unilateral optic neuropathy subject these values were 52.2%, 16% in the unaffected eye and 29.3%, 8.6% in the affected eye.

The portable pupillometer demonstrated pupillary dose response to stimulus duration and intensity. It recorded both maximum and post illumination pupillary responses to a 1s bright blue stimulus to be reduced in an eye with optic neuropathy compared with the fellow eye. The intereye difference for maximum constriction was larger in the optic neuropathy subject than the control subject. These results provide initial validation for our portable pupilometer.