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Abstract Details

Association between LDL-C/HDL-C ratio and Hemorrhagic Transformation in Acute Ischemic Stroke Patients
General Neurology
P1 - Poster Session 1 (5:30 PM-6:30 PM)
4-036
To explore the association between LDL-C/HDL-C ratio and hemorrhagic transformation (HT) in acute ischemic stroke (AIS) patients.

Low-density lipoprotein cholesterol (LDL-C) levels were negatively associated with HT, but high-density lipoprotein cholesterol (HDL-C)levels were positively associated with HT. The association between LDL-C/HDL-C ratio and HT in acute ischemic stroke (AIS) patients remains unclear.

Data from the Chengdu Stroke Registry on consecutive AIS patients admitted to West China Hospital within 7 days of stroke onset from January 2016 to June 2017 were included. Clinico-demographic characteristics including lipid profiles tests were collected. Patients were divided into three categories based on LDL-C/HDL-C ratio tertiles. HT was defined by the magnetic resonance imaging or computed tomography.

We enrolled 968 patients (612 males; mean age, 63.89±14.60years), of whom 116 patients (11.98%) presented with HT. According to LDL-C/HDL-C ratio tertiles (tertile 1<1.70; tertile2=1.70-2.48; and tertile3>2.48), all patients were divided into three categories including tertile 1(n=320, 190 males, mean age, 66.72±15.32years), tertile 2(n=330, 204 males, mean age, 63.39±14.34years) and tertile 3(n=318, 218 males, mean age, 61.56±13.65years). The number of HT was 55(17.2%), 31(9.1%) and 30(9,7%) from tertile 1 to tertile 3. After adjustment for age, male gender, atrial fibrillation, SBP and National Institutes of Health Stroke Scale score on admission, a low LDL-C/HDL-C ratio was significantly associated with HT (OR 0.517, 95%CI 0.308 to 0.866, P = 0.012).

Our research founded that a low LDL-C/HDL-C ratio was independently associated with HT in AIS patients within 7 days. Future work should be aimed to elucidate how lipid levels contribute to HT and explore comprehensive factors of predicting HT.

Authors/Disclosures
Yanan Wang
PRESENTER
No disclosure on file
No disclosure on file
Yajun Cheng No disclosure on file
No disclosure on file
No disclosure on file
Liu Ming No disclosure on file