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Abstract Details

Hemispheric Asymmetry Contributing to Socioemotional Behavior in Frontotemporal Dementia
Aging, Dementia, and Behavioral Neurology
P2 - Poster Session 2 (5:30 PM-6:30 PM)
9-003
To examine the social and emotional behaviors and asymmetric frontal and frontotemporal atrophy in behavioral variant Frontotemporal Dementia (bvFTD) patients.

Clinical studies report abnormal socioemotional behavior in patients with right frontotemporal disease, but neuroimaging studies of socioemotional behavior usually show bilateral activations in normal subjects.  This discrepancy suggests that impaired interhemispheric collaboration for socioemotional functions results from asymmetric frontotemporal disease.

In a two-part study, we evaluated patients who met Clinical Consensus Criteria for bvFTD using alternative socioemotional scales and alternative magnetic resonance imaging measures.  Part A compared 18 patients on scales of social dysfunction and emotional intelligence with degree of asymmetry in frontal lobe volumes.  Part B compared 24 patients on scales of social observation and emotional blunting with degree of frontotemporal cortical thickness.  

Both results showed that left or right hemispheric-specific contributions did not account for all socioemotional differences and that frontal lobe and frontotemporal differences in atrophy between the hemispheres accounted for significant variance in abnormalities in social and emotional behavior. 
The results did not reveal differential left or right hemispheric contributions to socioemotional behaviors; however, the inter-hemispheric absolute asymmetry (regardless of direction) accounted for significant variance on the Social Observation Scale and on caregiver-rated disinhibition and emotional blunting. The effect of asymmetry was not due to differences in dementia duration or severity. These findings indicate that degree of absolute hemispheric asymmetry itself contributes to socioemotional dysfunction, with implications for interhemispheric  interactions. Beyond absolute atrophy, the severity of socioemotional symptoms among patients with bvFTD may be related to the relative atrophy and involvement of one hemisphere in comparison to the other.
Authors/Disclosures
Leila Parand, MD (UCLA)
PRESENTER 		Dr. Parand has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Eli Lily. Dr. Parand has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Esai. Dr. Parand has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Peer view . Dr. Parand has received personal compensation in the range of $0-$499 for serving on a Speakers Bureau for Speaker Bureau .
No disclosure on file
No disclosure on file
No disclosure on file
Mario F. Mendez, MD, PhD, FAAN (VA Greater Los Angeles Healthcare System and UCLA) Dr. Mendez has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Medical 好色先生 Speakers' Bureau. Dr. Mendez has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for UpToDate. The institution of Dr. Mendez has received research support from NIH. Dr. Mendez has received publishing royalties from a publication relating to health care.