Abstract Details

Title Morphometric correlation of parkinsonian signs in different primary progressive aphasia syndromes

Topic Aging, Dementia, and Behavioral Neurology

Presentation(s) P2 - Poster Session 2 (5:30 PM-6:30 PM)

Poster/Presentation
Number 9-026

Objective The aim of this study is to investigate the association of primary progressive aphasia global and regional brain atrophy and their correlation with parkinsonian signs presenting in these patients.

Background Recent and previous evidence has shown the presence of parkinsonian signs in patients with diagnosis of probable primary progressive aphasia (PPA). Further evidence characterizes differential atrophy patterns in the three syndromes of PPA: non-fluent (PNFA), semantic dementia (SD) and logopenic (PLA).

Design/Methods We cross-sectionally assessed 15 PPA patients (5 PLA, 5 SD, 5 PNFA) with the motor part of the Unified Parkinson´s Disease Rating Scale (UPDRS-MD-III). MRI morphometry of grey matter was calculated and multiple regressions models were performed entering UPDRS-MD subscores as well as age and years of disease evolution.

Results

Results showed no differences among PPA syndromes in years of evolution, age (68,8±6 y.o.), gender (63% female) and total UPDRS-III score. PNFA patients showed more bradykinesia and gait/postural disorders, tremor was more frequently present in LA. Global morphometry showed atrophy of the frontal and tempora (Left>Right) in the whole PPA sample, whereas regional atrophy of subcortical areas associated with bradykinesia and gait/postural instability. UPDRS-III subscales: bradykinesia in PNFA correlated with frontal and temporal atrophy, and gait/postural disorders with subcortical atrophy. In LA, tremor correlated with parietal atrophy.

Conclusions We conclude that the presence of parkinsonism in PPA patients would not only characterize different subtypes of PPA, but also correspond to different patterns of atrophy.

Authors/Disclosures
PRESENTER	No disclosure on file
Carla F. Bolano Diaz, MD (John Walton Muscular Dystrophy Research Centre)	Dr. Bolano Diaz has nothing to disclose.
Guido D. Vazquez II, PhD (Neurociencias Favaloro)	Dr. Vazquez has nothing to disclose.
Franco E. Appiani, MD (ACE Alzheimer Cente - Instituto Catalán de Neurociencias Aplicadas)	Dr. Appiani has nothing to disclose.
Carlos Santiago Claverie, MD (Favaloro Foundation)	No disclosure on file
	No disclosure on file
Indira R. Garcia Cordero, PhD	No disclosure on file
	No disclosure on file
	No disclosure on file
Facundo Manes	No disclosure on file
	No disclosure on file

��ɫ��

��ɫ��