Abstract Details

Title The UCSF Memory and Aging Center: Early Developmental History Screening Questionnaire

Topic Aging, Dementia, and Behavioral Neurology

Presentation(s) P2 - Poster Session 2 (5:30 PM-6:30 PM)

Poster/Presentation
Number 9-029

Objective To establish the ability of a novel early developmental history (EDevHx) questionnaire to capture premorbid learning differences within healthy aging (NC), and dementia groups (Alzheimer’s disease and primary progressive aphasia).

Background Premorbid learning disabilities associate with domain-specific neurodegenerative disorders. To systematically capture self and/or informant-report of learning differences, we created a brief, comprehensive survey of early-childhood behavioral and cognitive performance, the EDevHx tool.

Design/Methods 365 NC and 353 dementia participants completed the EDevHx. Individuals were asked to select Likert scale responses (never, sometimes, often, or always) to questions regarding early childhood development and scholastic performance across multiple cognitive domains. NC participants were directed to complete the survey themselves, and informants were asked to complete the survey with or on behalf of patients with cognitive changes. Over half of NC and dementia groups also completed a longer, validated Adult Reading History Questionnaire (ARHQ).

Results In both NC and dementia groups, those who endorsed often or always in EDevHx language domain ratings possessed mean ARHQ scores in the dyslexic range (>0.3). ARHQ scores were statistically different and increased with EDevHx language domain ratings [(NC: never = 0.13±0.08; sometimes = 0.2±0.1; often = 0.32±0.16; always = 0.32±0.14; p<0.001) (Dementia: never = 0.17±0.13; sometimes = 0.29±0.15; often = 0.38±0.18; always = 0.44±0.12; p<0.001)]. Consistent with dyslexia population cognitive profiles, phonologic loop (digit span forwards) and decoding (pseudoword reading) were impaired in groups that endorsed often or always in the EDevHx language domain (digit span forwards: NC p<0.024, dementia p<0.037; pseudoword reading: dementia p<0.024).

Conclusions We designed the EDevHx screening tool to standardize collection of early life developmental history in aging and dementia populations across clinical and research evaluations. We demonstrate that the EDevHx questionnaire reliably captures history of language-based learning difficulties, in both healthy and neurodegenerative disease groups, and with results that correlate with expected dyslexia cognitive profiles.

Authors/Disclosures
PRESENTER	No disclosure on file
	No disclosure on file
	No disclosure on file
	No disclosure on file
	No disclosure on file
	No disclosure on file
	No disclosure on file
	No disclosure on file
Gil D. Rabinovici, MD, FAAN (UCSF Memory & Aging Center)	Dr. Rabinovici has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Eli Lilly. Dr. Rabinovici has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Alector. Dr. Rabinovici has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Merck. Dr. Rabinovici has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Roche. Dr. Rabinovici has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Genentech. Dr. Rabinovici has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Novo Norodisk. Dr. Rabinovici has received personal compensation in the range of $500-$4,999 for serving as a Consultant for C2N. Dr. Rabinovici has received personal compensation in the range of $10,000-$49,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Johnson & Joihnson. Dr. Rabinovici has received personal compensation in the range of $10,000-$49,999 for serving on a Speakers Bureau for Peerview. Dr. Rabinovici has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Medscape. Dr. Rabinovici has received personal compensation in the range of $10,000-$49,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for JAMA Neurology. Dr. Rabinovici has received personal compensation in the range of $10,000-$49,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for JAMA. The institution of Dr. Rabinovici has received research support from NIH. The institution of Dr. Rabinovici has received research support from American College of Radiology. The institution of Dr. Rabinovici has received research support from Alzheimer's Association. The institution of Dr. Rabinovici has received research support from Rainwater Charitable Foundation. Dr. Rabinovici has received personal compensation in the range of $500-$4,999 for serving as a Topic Chair, Course Director and teacher with AAN. Dr. Rabinovici has received personal compensation in the range of $500-$4,999 for serving as a Grant reviewer with NIH. Dr. Rabinovici has received personal compensation in the range of $500-$4,999 for serving as a Invited speaker with ANA.
Joel Kramer, PhD (UCSF Medical Center)	The institution of Dr. Kramer has received research support from tau consortium. Dr. Kramer has received publishing royalties from a publication relating to health care.
Bruce L. Miller, MD, FAAN (University of California, San Francisco)	Dr. Miller has nothing to disclose.
Maria Luisa Gorno Tempini, MD, PhD (UCSF Memory and Aging Center)	The institution of Dr. Gorno Tempini has received research support from the NIH.
Zachary Miller, MD (UCSF Memory and Aging Center)	Dr. Miller has nothing to disclose.

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