Abstract Details

Title Two Cases of Transient Global Amnesia in Marfan Syndrome

Topic Cerebrovascular Disease and Interventional Neurology

Presentation(s) P2 - Poster Session 2 (5:30 PM-6:30 PM)

Poster/Presentation
Number 3-064

Objective To discuss the presentation and underlying pathophysiology of transient global amnesia (TGA) in two patients with Marfan Syndrome.

Background TGA is characterized by the sudden onset of anterograde amnesia lasting up to 24 hours. The mean age of onset is between 60 and 65 years and it usually does not recur. The pathophysiology of TGA may involve a vascular mechanism of transient venous congestion or arterial ischemia. Although Marfan Syndrome is characterized by a strong predisposition for vascular disease, especially aortic root dilatation and dissection, there are no prior reports of TGA in Marfan Syndrome.

Design/Methods Report of two Marfan patients presenting with TGA.

Results Two patients with Marfan Syndrome presented with sudden onset anterograde amnesia lasting 8 to 10 hours. Both patients had a history of aortic root replacement, and family history of sudden death from aortic dissection. In each case, a complete work-up was otherwise normal and the diagnosis was TGA. The first patient was a 28-year-old male with no obvious trigger for the amnestic episode, and he had no TGA recurrence. The second patient was a 54-year-old female presenting after intense physical exertion. She had a second episode of TGA one year later associated with strong emotion, and a third episode two years after the initial event following prolonged heat exposure.

Conclusions Both patients had early presentations of transient global amnesia, and the second patient had three total episodes, which is rare. There are numerous reports of transient global amnesia concurrent with aortic dissection. Although our patients did not experience aortic dissection, their underlying connective tissue disorder and history of aortic root replacement may have made them more susceptible to transient disruptions in venous flow.

Authors/Disclosures
Kenneth A. Morris, MD, PhD (University of Colorado Health) PRESENTER	No disclosure on file
Alejandro A. Rabinstein, MD, FAAN (Mayo Clinic)	Dr. Rabinstein has received personal compensation in the range of $10,000-$49,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Boston Scientific. Dr. Rabinstein has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Shionogi . Dr. Rabinstein has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Chiesi. Dr. Rabinstein has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Ceribell. Dr. Rabinstein has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Neurocritical care/NCS-Springer. Dr. Rabinstein has received personal compensation in the range of $5,000-$9,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Wolters/UptoDate. Dr. Rabinstein has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for EBSCO/DynaMed. Dr. Rabinstein has received personal compensation in the range of $5,000-$9,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for AHA. Dr. Rabinstein has received publishing royalties from a publication relating to health care. Dr. Rabinstein has received publishing royalties from a publication relating to health care. Dr. Rabinstein has received publishing royalties from a publication relating to health care. Dr. Rabinstein has received publishing royalties from a publication relating to health care.
Nathan P. Young, DO (Mayo Clinic)	Dr. Young has nothing to disclose.

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