Abstract Details

Title Multifocal motor neuropathy: a rare and complex disease - an university center’s experience.

Topic Neuromuscular and Clinical Neurophysiology (EMG)

Presentation(s) P2 - Poster Session 2 (5:30 PM-6:30 PM)

Poster/Presentation
Number 12-017

Objective

To analyze the profile of the patients diagnosed with multifocal motor neuropathy (MMN) in a center specialized in peripheral nervous system diseases.

Background The MMN is a rare disease, acquired immune-mediated, characterized by asymmetric progressive paresis and atrophy without expressive sensory impairment. The electroneuromyography alterations are also needed to fulfill criteria, including those of the European Federation of Neurological Societies/Peripheral Nerve Society (EFNS/PNS).

Design/Methods

Forty-six medical charts were selected in a data basis, using the key words “CIDP” and “MMN”, from 1984 to 2018. Clinico-epidemiological data and complementary exams were analyzed and projected on a clinical evaluation card.

Results From the 46 medical charts, 8 fulfilled the ENFS/PNS for MMN. Fifty percent were women. The median of age at the beginning of the symptoms was 46. In 50% of the patients (4), the initial presentations were mono-symptomatic (motor or sensory/ upper or inferior limbs), of which 75% (3) were of motor symptoms on upper limbs and 25% (1), of sensory symptoms on upper limbs. Both motor and sensory symptoms on upper limbs occurred in 25% of the patients and motor on upper and inferior limbs, in the other 25%. The clinical grading score at the time of diagnosis was 1 in 62,5%, 2 in 25% and 3 in 12,5% of the patients. The median of the time between the beginning of the symptoms and the diagnosis was 24 months. The median of the Medical Research Council (MRC) sum score of the initial presentation was 55,5. MMN was defined in 62,5%, probable in 12,5% and possible in 25%.

Conclusions There was no difference between sexes. The sensory symptoms were present in 37,5% of the cases. The median of the time between the beginning of the symptoms and the diagnosis was too long.

Authors/Disclosures
Caroline L. Medeiros, Jr., MD (Hospital Universitario Antonio Pedro) PRESENTER	Dr. Medeiros has nothing to disclose.
Viviane T. Carvalho, MD (Federal Fluminense University)	Dr. Carvalho has nothing to disclose.
Arthur Ramalho Monfredinho, MD (University Hospital Antonio Pedro - Federal Fluminense University)	Dr. Ramalho Monfredinho has nothing to disclose.
Thiago A. Rodrigues, MD (Universidade Federal Fluminense)	Dr. Rodrigues has nothing to disclose.
Luis F. Maia (Unidate Clinica de Paramoloidose Hospital)	No disclosure on file
	No disclosure on file
	No disclosure on file
Eduardo R. Davidovich	Dr. Davidovich has nothing to disclose.
Camila Pupe, MD	Dr. Pupe has nothing to disclose.
Osvaldo J. Nascimento, MD, PhD, FAAN (Fluminense Federal University)	Dr. Nascimento has nothing to disclose.

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