Abstract Details

Title Quantitative EEG Burst Suppression Ratio and Patient Outcome in Refractory Status Epilepticus

Topic Epilepsy/Clinical Neurophysiology (EEG)

Presentation(s) P2 - Poster Session 2 (5:30 PM-6:30 PM)

Poster/Presentation
Number 6-020

Objective To determine whether there is an association between the quantitative burst suppression ratio (QBSR) and refractory status epilepticus (RSE) patient outcomes.

Background RSE patients are commonly treated with intravenous sedatives with the goal of obtaining a ‘burst suppression’ pattern on EEG. However, the optimal degree of EEG suppression is unclear. In this retrospective study, QBSRs were calculated using Persyst© software in RSE patients.

Design/Methods QBSR was generated for 24 adult RSE patients from all causes (excluding post-anoxic) admitted to the Health Sciences Centre in Winnipeg, Canada. QBSR was calculated per 10 second EEG epoch as the percentage of time during which EEG amplitude was less than 3 microvolts per millimetre. Patients discharged from ICU/hospital and/or survived to 3 months comprised the favourable group whereas the unfavourable group included patients who did not meet those criteria. Non-parametric statistical analysis compared the distribution of QBSRs between groups during each patient’s episode of RSE.

Results Over 135,000 EEG QBSR data points from 17 patients were included in the final analysis. Median QBSR was significantly higher in the favourable group (n=7) compared to the unfavorable group (0.87 vs. 0.47, p<0.001). Patients in the favourable group were less ill (mean adjusted status epilepticus severity score 3.14 vs. 4.2, p<0.05) and trended to younger age (mean 51 vs. 68.2 years, p=0.08). EEG monitoring duration did not significantly differ between groups (mean 8950.6 vs. 7370.1 ten second epochs).

Conclusions Our study found that median QBSR is associated with survival in patients with RSE, suggesting that heavier EEG suppression in patients with RSE may be associated with better outcomes. Similar to previous studies, patients who fared better were less ill. Our findings demonstrate the potential utility of QBSR as a quantitative EEG option to aid in the monitoring and treatment of RSE patients.

Authors/Disclosures
Neil Mehdiratta, MD (University of Manitoba, Health Science Center) PRESENTER	No disclosure on file
	No disclosure on file
Marcus Ng, MD (University of Manitoba)	The institution of Dr. Ng has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Paladin Canada. The institution of Dr. Ng has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Paladin Canada. Dr. Ng has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Journal of Clinical Neurophysiology. The institution of Dr. Ng has received research support from Eisai. The institution of Dr. Ng has received research support from Paladin Canada. Dr. Ng has received publishing royalties from a publication relating to health care.

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