Abstract Details

Title Implementation of the Liverpool Adverse Events Profile in Patients with Epilepsy at the University of Puerto Rico Epilepsy Clinics

Topic Epilepsy/Clinical Neurophysiology (EEG)

Presentation(s) P2 - Poster Session 2 (5:30 PM-6:30 PM)

Poster/Presentation
Number 6-036

Objective The aim of this study is to implement the Spanish version of the Liverpool Adverse Events Profile at the University of Puerto Rico Epilepsy Clinics, and evaluate for quality improvement purposes.

Background An estimated 50 million people worldwide are diagnosed with epilepsy, leading this to be one of the most common neurological conditions in existence. Approximately 70% of patients receiving treatment with anti-epileptic drugs (AED) achieve seizure control. However, these medications are accompanied with adverse effects that are crucial to identify, as they can significantly alter quality of life in this patient population with increased risk of anxiety and depression. The ability to quantify patients’ perception of side effects of AEDs is essential, highlighting the importance of tools such as the Liverpool Adverse Events Profile (LAEP). The LAEP presents a checklist of symptoms that individuals may have experienced in the last 4 weeks, rated using Likert scale responses. Around 40% of adults and 30% of children with epilepsy will be using AEDs for a period longer than 2 to 5 years, further strengthening the need for adequate side effect description.

Design/Methods The validated Spanish version of the LAEP in patients with epilepsy will be implemented as part of the quality measures evaluated at UPR Epilepsy clinics. Score will be documented annually for every patient and results will be discussed with the patient in order to address possible adverse effects reported.

Results Preliminary data shows that most common adverse event reported by patients as always or often a problem is tiredness (33%). Most common adverse events reported as sometimes a problem include memory problems (46.7%), disturbed sleep (46.7%), headache (40%), tiredness (40%).

Conclusions This systematic screening of adverse effects in AEDs can help optimize therapeutic levels while preventing toxicity. In addition, it can help us promptly identify mood side effects that can then be addressed.

Authors/Disclosures
PRESENTER	No disclosure on file
Sonia M. Caraballo-Cartagena, MD (Advocate Health Care)	Dr. Caraballo-Cartagena has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for UCB. Dr. Caraballo-Cartagena has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Argenx. Dr. Caraballo-Cartagena has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Alexion. Dr. Caraballo-Cartagena has received personal compensation in the range of $10,000-$49,999 for serving on a Speakers Bureau for UCB. Dr. Caraballo-Cartagena has received personal compensation in the range of $10,000-$49,999 for serving on a Speakers Bureau for Alexion. Dr. Caraballo-Cartagena has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Takeda. Dr. Caraballo-Cartagena has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Alnylam. Dr. Caraballo-Cartagena has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Argenx.
Ignacio L. Pita Garcia, MD	Dr. Pita Garcia has nothing to disclose.

��ɫ��

��ɫ��