There is an alternative transducer array placement configuration to treat infratentorial tumors using TTFields but coverage for posterior fossa glioblastoma is unknown.

Patient anatomy-based models were created by segmenting MRI images into tissue “masks”.  The physical properties and boundary conditions for physics modeling were set up within COMSOL Multiphysics.  Electric field maps were compared for models using conventional array placement for supratentorial tumors versus alternative array placement for infratentorial tumors.  Electric field–volume histograms (EVHs) and specific absorption rate–volume histograms (SARVHs) were constructed to evaluate volumetric differences between models.

The alternative array placement provides a higher coverage of electric field (+29%) to the posterior fossa glioblastoma when compared to the conventional configuration.