Abstract Details

Title Factors Associated with Tumour Recurrence in WHO Grade II Meningiomas

Topic Neuro-oncology

Presentation(s) P2 - Poster Session 2 (5:30 PM-6:30 PM)

Poster/Presentation
Number 7-031

Objective To characterize and investigate clinical factors associated with tumour recurrence in resected WHO Grade II meningiomas in our local population

Background World Health Organisation (WHO) Grade II meningiomas constitute 5-15% of all meningiomas and are associated with poorer prognosis, higher risk of recurrence and malignant transformation ^1,2. Clinical factors associated with these recurrences are not well understood³.

Design/Methods Retrospective review of histologically proven WHO Grade II Meningiomas diagnosed in two tertiary hospitals between September 2005 to February 2017. We collected patients’ age at diagnosis and gender, Simpsons grading, extent of surgical resection, mitotic indices on histology and post-operative treatment with radiotherapy. We also rated pre-operative magnetic resonance imaging for location and size of tumour as well as extent of perilesional oedema. Tumour recurrence was defined as growth of original or development of new extra-axial tumour on brain imaging, with or without histological confirmation.

Results A total of 63 patients (38 women; 25 men) were included. The median age at initial meningioma diagnosis was 58 (range 22-85) years. The commonest presenting symptoms were focal neurological deficit (n=20; 31.8%) and altered mental status (n=13; 20.6%). With a median follow-up of 58 months, 14 (22.2%) patients developed tumour recurrence. One of 4 patients who underwent surgery at recurrence showed malignant transformation to WHO grade III meningioma. The median time from initial diagnosis to tumour recurrence was 27 (range 6-77) months. Using univariate analysis, only mitotic indices on histology was associated with recurrence of tumour (p value = 0.006). Recurrence was not associated with age at diagnosis, gender, Simpsons grading, extent of surgical resection, post-operative radiotherapy, maximum diameter and volume of pre-operative tumour and perilesional edema.

Conclusions Recurrence of WHO Grade II Meningioma is associated with increase in mitotic indices but not other clinical features in our local population.

Authors/Disclosures
PRESENTER	No disclosure on file
	No disclosure on file
	No disclosure on file
	No disclosure on file
	No disclosure on file
Xuling Lin, MD (National Neuroscience Institute)	The institution of Dr. Lin has received research support from National Health Innovation Center.

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