好色先生

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Abstract Details

Activity-independent detection of mediation states in individuals with Parkinson’s disease using wearable sensors
Movement Disorders
P2 - Poster Session 2 (5:30 PM-6:30 PM)
10-004

We investigated whether wearable sensors can be used to provide objective measurements regarding the medication states of patients with Parkinson’s disease (PD) during their activities of daily living.

 
Motor fluctuations between akinesia (medication OFF) and mobile (medication ON) phases are one of the most prevalent complications of patients with Parkinson’s disease (PD), occurring in 50% of patients within 3 to 5 years of diagnosis and 80% of patients after 10 years. There is a need for a technology-based system that provides reliable and objective measurements of a patient’s  duration  medication OFF and ON phases that can be readily used by the clinician to make successful therapeutic adjustments. 
19 fluctuating PD subjects (age: 42-77, 14 males) were selected in this study. Two KinetiSense motion sensors were mounted on the most affected wrist and ankle to collect gyroscope signals. The participants performed seven daily living activities in their medication OFF and ON phases: resting, walking, drinking, dressing, hair brushing, unpacking groceries, and cutting food. A series of significant features were extracted from the motion signal. A medication OFF/ON classifier based on support vector machine with fuzzy labeling was trained using approximately 15% of four activities (ambulation, drinking, arm resting, and dressing) and tested on the remaining data.  

The trained classifier was able to detect medication states with 90.5% classification accuracy, 94.2% sensitivity, and 85.4% specificity. The average accuracy for the activities in the training phase was 91.3%, and for the new activities it was 88.4%, indicating that the algorithm is activity-independent and performs equally-well for all the seven activities.

Our algorithm would enable an easy-to-use sensor-based assessment system that is not task-based, which can provide accurate and timely information to address motor fluctuations. Use of such sensor data could considerably improve both the care delivery and quality of life for PD patients.
Authors/Disclosures
Murtadha Hssayeni
PRESENTER 		No disclosure on file
Michelle Burack, MD, PhD (You Centered Health Neurology, PLLC) No disclosure on file
Joohi Jimenez Shahed, MD, FAAN (Icahn School of Medicine at Mount Sinai) Dr. Jimenez Shahed has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Teva. Dr. Jimenez Shahed has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Medtronic. Dr. Jimenez Shahed has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Abbvie. Dr. Jimenez Shahed has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Amneal. Dr. Jimenez Shahed has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for BlueRock. Dr. Jimenez Shahed has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Treefrog. Dr. Jimenez Shahed has received personal compensation in the range of $500-$4,999 for serving as a Consultant for RebrAIn. Dr. Jimenez Shahed has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for BlueRock Therapeutics. Dr. Jimenez Shahed has received personal compensation in the range of $10,000-$49,999 for serving on a Scientific Advisory or Data Safety Monitoring board for PhotoPharmics. Dr. Jimenez Shahed has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Emalex. Dr. Jimenez Shahed has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Biohaven. The institution of Dr. Jimenez Shahed has received research support from Amneal. The institution of Dr. Jimenez Shahed has received research support from Annovis. The institution of Dr. Jimenez Shahed has received research support from SAGE. The institution of Dr. Jimenez Shahed has received research support from Ono Pharmaceuticals. The institution of Dr. Jimenez Shahed has received research support from BlueRock. The institution of Dr. Jimenez Shahed has received research support from Neuron23. Dr. Jimenez Shahed has received personal compensation in the range of $0-$499 for serving as a Faculty with Movement Disorders Society. Dr. Jimenez Shahed has received personal compensation in the range of $500-$4,999 for serving as a Faculty with 好色先生. Dr. Jimenez Shahed has received personal compensation in the range of $500-$4,999 for serving as a Grant Reviewer with Parkinson Foundation.
No disclosure on file