Abstract Details

Title The Effect of High-Intensity Exercise on Objective Sleep Outcomes in Parkinson’s Disease

Topic Movement Disorders

Presentation(s) P2 - Poster Session 2 (5:30 PM-6:30 PM)

Poster/Presentation
Number 10-022

Objective

Determine if high-intensity exercise, compared to a sleep hygiene control, improves objective sleep outcomes in Parkinson’s disease (PD).

Background Sleep dysfunction is common and disabling in persons with PD. Exercise improves motor symptoms, quality of life, and subjective sleep quality in PD, but there are no published studies reporting the influence of exercise on objective sleep outcomes.

Design/Methods Persons with PD (Hoehn & Yahr stage 2-3; age >45; and not in a regular exercise program) were randomized to a high-intensity exercise intervention (supervised exercise 3x/week for 16 weeks) (N=27) or a sleep hygiene control (N=28). Participants were evaluated with polysomnograpy at baseline and post-intervention. The change in sleep efficiency (percentage of time a person is in bed that he/she is actually sleeping) was the primary outcome, measured from baseline to post-intervention with repeated measures ANOVA and compared between groups for group x time interaction.

Results There were no differences between the groups in terms of age, sex, duration of disease, or MDS-UPDRS I-IV or total score. Participants in the exercise group had significant improvement in sleep efficiency compared to the sleep hygiene group (group x time interaction: F=16.0 p=0.0002). Other parameters of sleep architecture also improved in the exercise group compared to the sleep hygiene group including total sleep time, wake after sleep onset, and slow wave sleep.

Conclusions High intensity exercise improves objective sleep outcomes in patients with Parkinson’s disease. Further study is needed to determine the best exercise prescription for sleep in persons with PD.

Authors/Disclosures
Amy W. Amara, MD PhD (University of Colorado Anschutz Medical Center) PRESENTER	The institution of Dr. Amara has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Photopharmics, Inc. The institution of Dr. Amara has received research support from Michael J Fox Foundation for Parkinson's Research . The institution of Dr. Amara has received research support from Biogen Idec. The institution of Dr. Amara has received research support from NIH.
Allen Joop, MS (University of Alabama At Birmingham)	Mr. Joop has nothing to disclose.
Raima A. Memon, MBBS (University of Alabama At Birmingham)	Dr. Memon has nothing to disclose.
	No disclosure on file
	No disclosure on file
	No disclosure on file

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