Abstract Details

Title Determinants of Weight Change in Parkinson's Disease

Topic Movement Disorders

Presentation(s) P2 - Poster Session 2 (5:30 PM-6:30 PM)

Poster/Presentation
Number 10-027

Objective To investigate weight change in patients with Parkinson's disease (PD) over time and identify predictors of weight change.

Background Prominent weight loss is seen in a subset of PD patients, and has been associated with worse outcomes, including higher UPDRS scores (motor and total).

Design/Methods We analyzed longitudinal data collected over 16 years from PD patients for the HOME study (Health Outcomes Measurement) at University of Maryland PD Center. Patients with weight recorded at two visits one year apart were included. Weight change was defined as change in 5% of baseline weight, with unstable weight defined as loss or gain. Baseline characteristics of weight subgroups (stable, loss, or gain) were compared using chi-squares and ANOVA models.

Results

Weights were recorded for 3,544 pairs of contiguous annual visits among 1,143 PD patients. PD duration (time from diagnosis) at first visit ranged from 0-21 years (M±SD=4.3±5.1). Stable weight over one year was seen in n=2581 (73%), with n=532 (15%) weight loss and n=431 (12%) weight gain. Unstable weight was associated with worse PD severity (UPDRS total and motor) and disability (OARS) at baseline (p<.0001). Female gender, non-white race, and depression (BSI) were also associated with unstable weight (p<.05), with a similar trend for dyskinesia (p=.10). Dysphagia was more common with unstable than stable weight (p<.05). Older age was associated with weight loss more than stable weight or weight gain (p<.001). PD duration was not significantly related to weight change (p=.25).

Conclusions

Weight change of ≥5%/year was seen in >25% of visits in patients with PD. Greater severity of motor and non-motor impairments, greater disability, female gender, depression, and non-white race are associated with increased risk of weight change, both loss and gain. Unstable weight is seen throughout the course of Parkinson's disease and is a marker of motor and non-motor disease progression.

Authors/Disclosures
John H. Herndon, MD (Billings Clinic) PRESENTER	No disclosure on file
	No disclosure on file
Ann Gruber-Baldini	No disclosure on file
Joseph M. Savitt, MD, PhD (University of Maryland)	The institution of Dr. Savitt has received research support from Bial. The institution of Dr. Savitt has received research support from UCB.
F. Rainer Von Coelln, MD (University of Maryland School of Medicine)	The institution of Dr. Von Coelln has received research support from University of Maryland and Maryland State Goverment. Dr. Von Coelln has received intellectual property interests from a discovery or technology relating to health care.
Stephen G. Reich, MD, FAAN (Univ of MD Hospital/Dept of Neuro)	Dr. Reich has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Best Doctors. Dr. Reich has received personal compensation in the range of $500-$4,999 for serving as a Consultant for UpToDate. Dr. Reich has received personal compensation in the range of $10,000-$49,999 for serving as an Expert Witness for Various law firms. Dr. Reich has received publishing royalties from a publication relating to health care. Dr. Reich has received publishing royalties from a publication relating to health care.
Lisa M. Shulman, MD, FAAN (University of Maryland School of Medicine)	The institution of Dr. Shulman has received research support from NIH. Dr. Shulman has received publishing royalties from a publication relating to health care. Dr. Shulman has received publishing royalties from a publication relating to health care.

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