好色先生

好色先生

Explore the latest content from across our publications
Join The AAN

Log In

Forgot Password?
Create New Account

Loading... please wait

Abstract Details

Anxiety and depression are associated with levodopa-responsive, but not levodopa-unresponsive, freezing of gait in Parkinson’s disease
Movement Disorders
P2 - Poster Session 2 (5:30 PM-6:30 PM)
10-031

To determine whether different associations exist between affective symptoms and levodopa-responsive and –unresponsive freezing of gait (FOG) in Parkinson’s disease (PD).

Affective symptoms including depression and anxiety are reported to be associated with FOG. However, there are at least two subtypes of FOG – levodopa-responsive and levodopa-unresponsive – that may reflect different underlying pathophysiology and that may have different associations with affective symptoms.

N=125 PD patients were assessed for depression and anxiety using a Structured Clinical Interview (SCID), the Beck Depression Inventory-II (BDI-II) and the Beck Anxiety Inventory (BAI). FOG subtype (no freezing, “NOFOG” vs. levodopa-responsive freezing, “RFOG,” vs. levodopa-unresponsive freezing, “URFOG”) was determined with FOG-Q and self-report. Associations between the presence of RFOG or URFOG and 1) presence vs. absence of depression and anxiety on the SCID, and 2) severity of depression and anxiety on the BDI-II and BAI were determined with multinomial logistic regression.

BDI-II and BAI scores were dichotomized about cutpoints from the literature as indicative of depression and anxiety, respectively. Analyses controlled for age, sex, education, MoCA score, UPDRS-III score, and disease duration.
Mean age and disease duration were 65±8 and 8±4 years. RFOG, URFOG, and depression/anxiety (SCID) were present in 14%, 11%, and 18% of the sample. Mean scores on BDI-II and BAI were 9.5±6.7 and 8.8±7.7. Current depression (SCID) was associated with significantly increased odds of RFOG (OR [95% CI]: 4.84 [1.24-19.00]; P=0.02). A similar, marginally-significant association was identified for current anxiety and RFOG (3.90 [0.92-16.50]; P=0.07). In contrast, associations between depression or anxiety and URFOG were not significant (OR: 0.91, depression; 1.05, anxiety). Similar patterns were identified for dichotomized BDI-II and BAI scores.

These results suggest that anxiety or depression may be differentially associated with levodopa-responsive FOG. Levodopa-unresponsive FOG may reflect distinct underlying pathophysiology with potentially less interaction with limbic cortico-basal ganglia pathways.
Authors/Disclosures
Johnathan L. McKay, PhD (Emory University)
PRESENTER 		The institution of Dr. McKay has received research support from NIH. The institution of Dr. McKay has received research support from the McCamish Foundation.
Felicia Goldstein No disclosure on file
Stewart A. Factor, DO, FAAN (Emory University School of Medicine) Dr. Factor has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Neurocrine. Dr. Factor has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Biogen. Dr. Factor has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Takeda. The institution of Dr. Factor has received research support from Biohaven. The institution of Dr. Factor has received research support from Neurocrine. The institution of Dr. Factor has received research support from Supernus. The institution of Dr. Factor has received research support from Sun Pharmaceuticals Advanced Research Company. The institution of Dr. Factor has received research support from Aspen. The institution of Dr. Factor has received research support from RHO. Dr. Factor has received publishing royalties from a publication relating to health care. Dr. Factor has received publishing royalties from a publication relating to health care. Dr. Factor has received publishing royalties from a publication relating to health care. Dr. Factor has received publishing royalties from a publication relating to health care.