Abstract Details

Title Heart Rate Variability And Sympathetic Skin Response In Idiopathic And Leucine-Rich Repeat Kinase 2-Associated Parkinson's Disease

Topic Movement Disorders

Presentation(s) P2 - Poster Session 2 (5:30 PM-6:30 PM)

Poster/Presentation
Number 10-032

Objective

The aim of this study was to investigate and compare both Heart rate variability (HRV) and sympathetic skin response (SSR) in leucine-rich repeat kinase 2-associated PD (LRRK2-PD) and idiopathic PD (iPD).

Background

Reduced HRV is common in iPD. Little is known about HRV and SSR in LRRK2-PD. Rare recent reports indicated intact HRV in LRRK2-PD.

Design/Methods Prospective study (from January 2015 to September 2018) including 93 patients diagnosed with PD: thirty-seven G2019S LRRK2-PD (four homozygous and 33 heterozygous) and fifty-six iPD. The two groups were matched for sex and age, age of onset of parkinsonism and dysautonomia, UPDRS and Hoehn and Yahr scores. The sympathetic autonomic system (AS) was assessed with the SSR evaluated at the four limbs. Absent SSR at either one or more extremities was regarded as abnormal. Parasympathetic AS was assessed according to Ewing’s battery (Heart rate variation to deep breathing (HR-DB), to Valsalva(HR-V), heart rate response to standing(HR-S)).

Results

Neurophysiologic dysautonomia was found respectively in 76% of LRRK2-PD and 70% of iPD (p=0.348). HRV was reduced in 64% of LRRK2-PD and 64,2% of iPD (p=0.571). No differences were found in the prevalence and values of the three tests of Ewing's battery. Sympathetic dysautonomia with abnormal SSR was found 37,8% LRRK2-PD and 23,2% iPD (p=0,099).

Conclusions

Reduced HRV was common in both iPD and LRRK2-PD patients. Parasympathetic dysfunction was more frequent than sympathetic dyautonomia. Our study showed no statistically significant differences between idiopathic and LRRK2-PD, contrasting with previous studies in the literature. Further studies on larger cohorts are required to confirm these findings.

Authors/Disclosures
Amina Nasri, MD (Department of Neurology, Razi University Hospital) PRESENTER	Dr. Nasri has nothing to disclose.
	No disclosure on file
Imen Kacem, MD (Department of Neurology)	Dr. Kacem has nothing to disclose.
	No disclosure on file
Saloua Mrabet, MD (Razi University Hospital)	Dr. Mrabet has nothing to disclose.
	No disclosure on file
	No disclosure on file
	No disclosure on file
	No disclosure on file
Chokri A. Mhiri, MD (Habib Bourguiba Hospital)	Prof. Mhiri has received personal compensation for serving as an employee of Hikma. Prof. Mhiri has received personal compensation for serving as an employee of Sanofi Genzyme. Prof. Mhiri has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Novartis. Prof. Mhiri has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Roche.
Riadh Gouider, MD, FAAN (Erazi Hospital)	Dr. Gouider has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Merck. Dr. Gouider has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Biogen. Dr. Gouider has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Roche. Dr. Gouider has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Sanofi. Dr. Gouider has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Hikma. The institution of Dr. Gouider has received research support from Clinical Investigation Center. The institution of Dr. Gouider has received research support from Menactrims.

��ɫ��

��ɫ��