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Abstract Details

Comparison of EEG Connectivity measures and Frequency analysis for identification of patients with Mild Cognitive Impairment in Parkinson´s disease – a Random Forest Analysis
Movement Disorders
P2 - Poster Session 2 (5:30 PM-6:30 PM)
10-043
To investigate EEG connectivity features (Phase Lag Index, PLI) in Parkinson’s disease patients with Mild Cognitive Impairment (MCI) and to assess whether they perform better than frequency measures for classifying PD-MCI from PD Non-MCI patients.

Mild Cognitive Impairment is an intermediate condition between non-altered cognition and dementia, and the progression rate of MCI to PD-D over 4 – 12 years is 45-60% (D. Aarsland et al. 2001)(Levy et al. 2002)(Buter et al. 2008). Identifying PD patients with incipient cognitive decline is of major importance for clinicians and researchers.

 

EEG data for groups of 27 PD patients with MCI and 43 PD patients without cognitive impairment were recorded using a high-resolution recording system. 66 Frequency and 330 Phase Lag Index measures were extracted. Random Forest algorithm was applied to identify important features for classifying PD-MCI from Non-MCI patients. Scores from five cognitive domains and overall cognitive scores were correlated with Phase Lag Index (PLI) and frequency measures.

 

Phase Lag Index measures classify PD-MCI patients from Non-MCI patients better than frequency measures, and there is no additional improvement in prediction by combining the two sets of measures. PLI in theta band is important for identifying patients with cognitive decline. Amongst all tested cognitive domains (Memory, Working Memory, Attention, Executive Function, Visual-Spatial Function), the most significant correlations with PLI measures were seen for Memory domain with theta PLI.

Phase Lag Index is an effective QEEG feature in identifying PD patients with Mild Cognitive Impairment.

 

Authors/Disclosures
Menorca Chaturvedi (Universitz Hospital Basel)
PRESENTER
No disclosure on file
No disclosure on file
Florian Hatz, MD No disclosure on file
No disclosure on file
No disclosure on file
No disclosure on file
Peter Fuhr, MD, FAAN The institution of Dr. Fuhr has received research support from Roche.
No disclosure on file