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Abstract Details

Longitudinal Cortical Changes Associated With Apathy in Parkinson’s Disease
Movement Disorders
P2 - Poster Session 2 (5:30 PM-6:30 PM)
10-044
To follow clinical/cognitive and cortical thickness (CT) changes in Parkinson’s disease (PD) patients with stable apathy (PD-sAp), without apathy (PD-noAp), and patients who developed apathy (PD-cAp) during 3 year follow up.
Apathy can influence the disease progression in PD.
We selected 96 patients with known apathy outcome at the initial exam or during 3 years of follow-up and 46 age- and sex-matched controls. We identified 37 PD-sAp, 33 PD-noAp, 26 PD-cAp patients. Patients and controls underwent clinical/neuropsychological evaluations and 3D T1-weighted MRI scans at baseline. Patients performed evaluations also once a year for 3 years. CT at baseline and over time was investigated within and between groups adjusting for age, disease severity, global cognition and mood.
At baseline, PD-cAp patients had higher age at disease onset relative to PD-noAp and lower disease severity and shorter disease duration relative to other patient groups. At baseline, the PD-sAp and PD-cAp groups showed worse memory abilities relative to PD-noAp. Over time, apathy worsened significantly every year in the PD-cAp group only. At baseline, PD-sAp patients showed cortical atrophy of bilateral fronto-temporo-parietal areas relative to controls and of left anterior cingulate and superior temporal gyri compared to the other patient groups. PD-sAp did not accumulate further cortical damage overtime. A greater progression of cortical thinning of the right superior temporal, inferior frontal and parietal regions was observed in PD-cAp relative to PD-noAp patients.
This study assessed the longitudinal cortical alteration associated with apathy in PD. We suggested that PD-sAp and PD-cAp are characterized by similar cognitive profile already in the early phase of the disease and by a similar pattern of cortical alterations overtime, involving the right superior temporal, inferior frontal and parietal regions.
Authors/Disclosures

PRESENTER 		No disclosure on file
Elisa Canu (Ospedale San Raffaele) The institution of Elisa Canu has received research support from Italian Ministry of Health .
No disclosure on file
Iva Stankovic (Neurology Clinic, Clinical Center of Serbia, University of Belgrade) Iva Stankovic has nothing to disclose.
Silvia Basaia Silvia Basaia has nothing to disclose.
No disclosure on file
No disclosure on file
No disclosure on file
Elka Stefanova No disclosure on file
Vladimir S. Kostic, MD, PhD (Institute of Neurology CCS) Dr. Kostic has received personal compensation in the range of $0-$499 for serving on a Speakers Bureau for Roche. An immediate family member of Dr. Kostic has received personal compensation in the range of $0-$499 for serving on a Speakers Bureau for Alkaloid. The institution of Dr. Kostic has received research support from Ministry of 好色先生, Science and Technological Development of Serbia.
Massimo Filippi, MD, FAAN (Ospedale San Raffaele, Neuroimaging Research Unit) Dr. Filippi has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Alexion, Almirall, Biogen, Merck, Novartis, Roche, Sanofi. Dr. Filippi has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Alexion, Biogen, Bristol-Myers Squibb, Merck, Novartis, Roche, Sanofi, Sanofi-Aventis, Sanofi-Genzyme, Takeda. Dr. Filippi has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Bayer, Biogen, Celgene, Chiesi Italia SpA, Eli Lilly, Genzyme, Janssen, Merck-Serono, Neopharmed Gentili, Novartis, Novo Nordisk, Roche, Sanofi, Takeda, and TEVA. Dr. Filippi has received personal compensation in the range of $10,000-$49,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Springer Nature. The institution of Dr. Filippi has received research support from Biogen Idec, Merck-Serono, Novartis, Roche, the Italian Ministry of Health, the Italian Ministry of University and Research, and Fondazione Italiana Sclerosi Multipla.
Federica Agosta (San Raffaele Scientific Institute) Federica Agosta has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Philips. Federica Agosta has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Elsevier INC.