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Abstract Details

ENIGMA Military Brain Injury: Altered Subcortical Volume in Chronic TBI Revealed by Mega-Analysis
Neuro Trauma, Critical Care, and Sports Neurology
P2 - Poster Session 2 (5:30 PM-6:30 PM)
4-061

To identify alterations in subcortical gray matter (GM) volume in Active Duty Service Members (ADSM) and Veterans of the United States military with history of traumatic brain injury (TBI), with greater power from multi-site mega-analysis.

TBI is one of the most common injuries affecting armed service members across the world. Injuries can affect combat readiness and can lead to long-term cognitive impairments and adverse health consequences. Altered subcortical GM volume may contribute to poor outcome. Reliable neuroimaging biomarkers of TBI have been elusive, often due to small sample size.

Participants were assessed through three different projects – DoD Alzheimer’s Disease Neuroimaging Initiative, Imaging Support of Study of Cognitive Rehabilitation Effectiveness in Mild Traumatic Brain Injury, and Chronic Effects of Neurotrauma Consortium, totaling 199 participants reporting at least one TBI (178M/21F) and 170 participants without history of TBI (153M/17F). Participants were between 18-83 years old. T1-weighted MR images were processed using FreeSurfer v5.3 and volume estimates of the thalamus, caudate, putamen, hippocampus, amygdala, nucleus accumbens, globus pallidus, and lateral ventricles were extracted using a standard protocol (). TBI versus control effect sizes were calculated across sites using random effects to control for site effects, including age, sex, education, and intracranial volume as covariates.

We found significantly smaller left thalamic volume in the TBI group (t(367)=-3.0, p=0.0025). Within female participants (21 TBI/17 controls), those with TBI showed a larger putamen (t(36)=2.3, p=0.03). There was a sex-by-diagnosis effect in the left and right thalamus (left t(367)=2.8, p=0.0054; right t(367)=2.7, p=0.0066).

We report reduced thalamic volume in Veterans and ADSM with history of TBI. Altered thalamic volume may contribute to motor, cognitive and other symptoms post-injury. Future studies on a larger sample need to verify a potential effect of sex. Future work will also examine associations of subcortical GM volume with clinical outcome measures.

Authors/Disclosures

PRESENTER 		No disclosure on file
Elisabeth Wilde Elisabeth Wilde has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Neuropsychology. The institution of Elisabeth Wilde has received research support from CDMRP/DoD. The institution of Elisabeth Wilde has received research support from VA. The institution of Elisabeth Wilde has received research support from NIH. The institution of Elisabeth Wilde has received research support from Cohen Veteran Biosciences.
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Erin D. Bigler, PhD (Erin D. Bigler, Ph.D.) Dr. Bigler has received personal compensation in the range of $50,000-$99,999 for serving as an Expert Witness for Erin D. Bigler, Ph.D., Private Consulting Practice. Dr. Bigler has received publishing royalties from a publication relating to health care.
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Inga K. Koerte, MD, PhD (Ludwig-Maximilians-Universitat) An immediate family member of Prof. Koerte has stock in Siemens Healthineers. The institution of Prof. Koerte has received research support from NINDS. The institution of Prof. Koerte has received research support from Abbott Inc.. The institution of Prof. Koerte has received research support from European Research Council. The institution of Prof. Koerte has received research support from German Ministry of Research and 好色先生 . Prof. Koerte has received publishing royalties from a publication relating to health care. Prof. Koerte has a non-compensated relationship as a Vice President with European Neurotrauma Organization that is relevant to AAN interests or activities. Prof. Koerte has a non-compensated relationship as a European Editor with Journal of Neurotrauma that is relevant to AAN interests or activities.
Martha Shenton Martha Shenton has nothing to disclose.
Harvey S. Levin, PhD (Dept of Physical Medicine & Rehab Baylor College of Medicine) No disclosure on file
Sidney Hinds, MD, FAAN (SCS Consulting, LLC) An immediate family member of Dr. Hinds has received personal compensation for serving as an employee of Henry Jackson Foundation. Dr. Hinds has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Otolith. Dr. Hinds has received personal compensation in the range of $500-$4,999 for serving as a Consultant for ICON. Dr. Hinds has received personal compensation in the range of $500-$4,999 for serving as a Consultant for The Conafay Group. Dr. Hinds has received research support from Uniformed Service University. Dr. Hinds has received personal compensation in the range of $500-$4,999 for serving as a Panel member with Congressionally Directed Medical Research Program. Dr. Hinds has a non-compensated relationship as a Ex Offcio Board member with NINDS/NANDS that is relevant to AAN interests or activities.
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Paul M. Thompson, PhD (USC) No disclosure on file
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