Abstract Details

Title The Impact of Traumatic Brain Injury on Arterial Compliance and Cerebral Blood Flow

Topic Neuro Trauma, Critical Care, and Sports Neurology

Presentation(s) P2 - Poster Session 2 (5:30 PM-6:30 PM)

Poster/Presentation
Number 4-064

Objective

To investigate the impact of traumatic brain injury (TBI) on central arterial compliance and cerebral blood flow (CBF) pulsatility in the chronic state.

Background

TBI in chronic state may alter arterial compliance and CBF. Central elastic arteries effectively buffer pressure and blood flow fluctuation generated by cardiac contraction, producing less pulsatile CBF. Aging impairs this ability, increasing pulsatile fluctuation in the cerebral vasculature. However, the impact of TBI on arterial compliance and pulsatile CBF in the chronic state remains unknown.

Design/Methods 23 patients with a history of mild to moderate TBI (TBI, 11 women) and 25 participants without history of TBI (NC, 11 women) were recruited. To determine the age effect, each group was divided into young (19-44 years) and middle-age (45-63 years) groups. The right common carotid arterial compliance was calculated from the ratio between the diameter change (via ultrasound) and the pressure change (via applanation tonometry). The ipsilateral middle cerebral artery blood flow velocity (CBFV) was measured via Transcranial Doppler. Pulsatility index (PI) was calculated by (100*(systolic CBFV-diastolic CBFV))⁄(mean CBFV).

Results

Carotid arterial compliance and PI did not show statistical differences between TBI and NC groups. The negative correlation between arterial compliance and age was greater for the TBI group (r=-.759, p<0.05) compared to the NC group (r=-.483, p<.05). In the middle-age groups, lower arterial compliance (0.10+0.01 vs. 0.12+.02, p<0.05) and higher PI (93+12 vs. 85+8, p<0.05) in the TBI group compared to the NC group were observed. No differences were observed in the young groups.

Conclusions

In the middle-aged group, reduction of carotid arterial compliance and augmented CBF pulsatility were observed in the TBI group compared to the NC group. The same phenomenon was not observed in younger groups. These findings suggest that TBI enhances the aging process of central arterial compliance and increase CBF fluctuation when TBI occurs after middle-age.

Authors/Disclosures
PRESENTER	No disclosure on file
Tsubasa Tomoto, PhD	Dr. Tomoto has nothing to disclose.
	No disclosure on file
	No disclosure on file
	No disclosure on file
	No disclosure on file
Kan Ding, MD (UT Southwestern Medical Center)	The institution of Dr. Ding has received research support from National Institute of Aging. The institution of Dr. Ding has received research support from NINDS.

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