Abstract Details Title Serum Phosphate Levels in Patients with Migraine Topic Headache Presentation(s) P3 - Poster Session 3 (5:30 PM-6:30 PM) Poster/Presentation Number 13-014 Objective To investigate the relationship between serum phosphate levels and presence of migraine. Background Migraine is a neurovascular disease characterized of chronic recurrent episodic headache attacks. Neurogenic inflammation is a well-known component among complexed migraine pathophysiology. Phosphate overloading was reported to induce systemic and vascular inflammation. Little is known about the relationship between serum phosphate levels and presence of migraine. Design/Methods We conducted a retrospective case-control study using a headache registry. Case subjects were first-visit migraine patients aged 19–59. We assessed serum phosphate levels of case subjects compared with 1:1 age- and sex-matched healthy control subjects who underwent health checkup and had no headache history. Results Of 148 migraine patients (mean age: 39.4 ± 10.7 years; female: 70.3%), serum phosphate levels were significantly higher than those of control subjects (3.69±0.52 vs. 3.55±0.45; p=0.016). The proportions of migraine patients were 38.4% and 63.3% in the lowest and highest quartiles of serum phosphate levels, respectively (p=0.026). Conclusions In this case-control study, serum phosphate levels were higher in migraine patients compared with control subjects, suggesting that elevated serum phosphate levels may underlie the pathophysiology of migraine. Authors/Disclosures PRESENTER No disclosure on file Byung-Su Kim Byung-Su Kim has nothing to disclose.