Our aim was to study the language and cognitive features associated to a new proposal of classification of primary progressive aphasia (PPA).

Primary progressive aphasia (PPA) is a clinical syndrome of neurodegenerative origin. Currently, three main variants (non-fluent, semantic, and logopenic) are recognized with the last consensus criteria published in 2011. This classification has improved the clinical-pathological correlation. However, there is some controversy about the existence of some additional subtypes.

Non-fluent type 1 showed a greater impairment in repetition of sentences and reading of irregular words in comparison to non-fluent type 2. Conversely, this group showed a higher degree of apraxia of speech. Non-fluent type 1 differed from both logopenic subtypes only in buccofacial apraxia, which was more impaired in non-fluent type 1. Logopenic variant type 1 showed a greater degree of impairment in action naming in comparison to logopenic type 2. Each subtype of PPA was associated to specific brain regions in voxel-based brain mapping analysis. 

Our study supports the existence of five variants of PPA. These variants show some differences in language and FDG-PET imaging characteristics. Future studies should determine if this classification could improve the clinical-pathological correlation.