Abstract Details

Title LIFEware Life Satisfaction and Pessimism are Correlated with the Beck Depression Inventory-Fast Screen and with Disability Progression in Individuals with Multiple Sclerosis

Topic Multiple Sclerosis

Presentation(s) P3 - Poster Session 3 (5:30 PM-6:30 PM)

Poster/Presentation
Number 15-009

Objective To investigate the correlations between single-item psychosocial LIFEware™ metrics and the Beck Depression Inventory-fast screen (BDI-fs) in people with MS (pwMS).

Background Depression is an extremely common comorbidity in multiple sclerosis (MS). The LIFEware™ system is a short, patient-reported outcomes (PRO) questionnaire assessing physical and psychosocial limitations that includes several single-item measurements associated with mood.

Design/Methods MS patients were extracted from the prospective Cardiovascular, Environmental and Genetic (CEG) study. The LIFEware™ psychosocial measures were completed by 134 pwMS who simultaneously completed the validated BDI-fs. Pearson correlations were calculated between the BDI-fs and the following LIFEware™ measures: life satisfaction, loneliness, pessimism, tension, panic, annoyance, morbid mood and guilt. Correlations between the LIFEware™ psychosocial measures, BDI-fs and the Expanded Disability Status Scale (EDSS) were also calculated.

Results LIFEware™ pessimism, loneliness and life satisfaction were most strongly correlated with BDI-fs (r²=0.56, 0.45 and -0.50, respectively; all p-values<0.001). When stratified by sex, life satisfaction in males was most strongly correlated with BDI-fs (r²=-0.66, p-value<0.001), while pessimism in females was most strongly correlated with BDI-fs (r²=0.55, p-value<0.001). Similar results were identified in aging pwMS (≥55 years of age) where both life satisfaction and pessimism were most strongly correlated with BDI-fs (r²=-0.63 and 0.69, respectively, both p-values<0.001). When examining correlations with disability progression, the BDI-fs, LIFEware™ life satisfaction, and pessimism were correlated with EDSS (r²=0.18 for the BDI-fs, r²=-0.27 for life satisfaction, and r²=0.17 for pessimism, all p-values<0.05).

Conclusions LIFEware™ psychosocial measures, particularly life satisfaction and pessimism, and the BDI-fs are highly correlated in pwMS. These measures were also statistically significantly, though modestly, correlated with disability progression.

Authors/Disclosures
Bianca Weinstock-Guttman, MD (Department of Neurology, University At Buffalo) PRESENTER	Dr. Weinstock-Guttman has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Biogen. Dr. Weinstock-Guttman has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Genentech. Dr. Weinstock-Guttman has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Novartis . Dr. Weinstock-Guttman has received personal compensation in the range of $500-$4,999 for serving as a Consultant for EMD Serono. Dr. Weinstock-Guttman has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Abbvie. Dr. Weinstock-Guttman has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Genzyme &Sanofi. Dr. Weinstock-Guttman has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Janssen . Dr. Weinstock-Guttman has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Bayer. Dr. Weinstock-Guttman has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Horizon. Dr. Weinstock-Guttman has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Genentech. Dr. Weinstock-Guttman has received personal compensation in the range of $0-$499 for serving on a Scientific Advisory or Data Safety Monitoring board for Novartis. Dr. Weinstock-Guttman has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Biogen. Dr. Weinstock-Guttman has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Janssen. Dr. Weinstock-Guttman has received personal compensation in the range of $0-$499 for serving as a Reviewer with NIH.
Katelyn S. Kavak (Jacobs MS Treatment and Research Center)	Ms. Kavak has nothing to disclose.
Dejan Jakimovski, MD, PhD (Buffalo Neuroimaging Analysis Center, University at Buffalo)	Dr. Jakimovski has nothing to disclose.
Osman Ozel, MD (Houston Methodist Hospital)	Dr. Ozel has nothing to disclose.
Ralph H. Benedict, PhD (University At Buffalo)	Dr. Benedict has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Roche. Dr. Benedict has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Sanofi. Dr. Benedict has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Bristol Meyers Squibb. Dr. Benedict has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Immunic Therapeutics. Dr. Benedict has received intellectual property interests from a discovery or technology relating to health care.
Robert Zivadinov, MD, PhD, FAAN (Buffalo Neuroimaging Analysis Center)	The institution of Dr. Zivadinov has received personal compensation in the range of $500-$4,999 for serving as a Consultant for BMS. The institution of Dr. Zivadinov has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Omnicuris. The institution of Dr. Zivadinov has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Myrobalan. Dr. Zivadinov has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Sanofi. Dr. Zivadinov has received personal compensation in the range of $10,000-$49,999 for serving on a Speakers Bureau for EMD Serono. Dr. Zivadinov has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Bristol Myers Squibb. The institution of Dr. Zivadinov has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Biogen.
Caila B. Vaughn, PhD (UB Neurology)	No disclosure on file

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