Abstract Details

Title Association Between Recent Cannabis Use and Acute Ischemic Stroke

Topic Cerebrovascular Disease and Interventional Neurology

Presentation(s) P3 - Poster Session 3 (5:30 PM-6:30 PM)

Poster/Presentation
Number 3-012

Objective In this study we aim to determine the association of acute ischemic stroke and recent cannabis use among patients admitted in the only tertiary academic medical center in Mississippi.

Background Studies that have analyzed the association between cannabis use and acute ischemic stroke have provided conflicting results.

Design/Methods A retrospective observational cohort study was performed utilizing the institutional patient cohort explorer. All adult patients 18 years and older admitted from January 1, 2015 to December 31, 2017 were screened for the inclusion criteria. Only the patients who underwent urine toxicology testing were included in the analysis. Recent cannabis use was defined as having a positive urine drug screen for cannabinoid. The unadjusted risk ratio was determined. Multivariate logistic regression analysis was utilized to study the independent association between recent cannabis use and acute ischemic stroke.

Results A total of 9,350 patients with acute ischemic stroke and urine toxicology testing were included for analysis. Patients with TIA, intracranial hemorrhage, and those with polysubstance use were excluded. Eighteen percent (1,643) of the patients had a positive urine cannabis test. The unadjusted risk ratio showed a 50% decrease in risk of acute ischemic stroke among cannabis users (RR = 0.505, P<0.000, 0.425 – 0.600). The effect was lost after adjusting for age, race/ethnicity, sickle cell disease, dyslipidemia, hypertension, obesity, diabetes mellitus, cigarette smoking, atrial fibrillation, and other cardiac conditions (OR 1.038, P=0.802, 0.773-1.394).

Conclusions This is the first study analyzing the association of cannabis use and acute ischemic stroke using the admission urine toxicology test. Consistent with some studies, this study shows that recent cannabis use is not an independent risk factor for ischemic stroke. Further studies utilizing urine toxicology tests with a larger sample size should be done.

Authors/Disclosures
Carmela San Luis, MD (Guthrie Hospital) PRESENTER	No disclosure on file
Shashank Shekhar, MBBS	The institution of Dr. Shekhar has received research support from Sponsor Department of Health and Human Services. The institution of Dr. Shekhar has received research support from PockitDx.
Rebecca L. Sugg, MD, FAAN (The University of South Alabama Medical Center)	Dr. Sugg has nothing to disclose.
Christa O'hana S. Nobleza, MD	Dr. Nobleza has nothing to disclose.
Shreyas Gangadhara, MD, FAAN (University of Mississippi Medical Center)	Dr. Gangadhara has nothing to disclose.

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