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Abstract Details

Proportional Recovery in Post-Stroke Aphasia
Cerebrovascular Disease and Interventional Neurology
P3 - Poster Session 3 (5:30 PM-6:30 PM)
3-039
To assess the proportional relationship between the initial severity of aphasia and the amount of recovery in specific areas of language comprehension and production.

Motor function recovery after stroke has previously been well described as a recovery of 70% of the initial impairment when the initial impairment was mild to moderate. Two previous studies have found a similar recovery of 70% for aphasia, but these studies examined overall aphasia severity rather than specific language abilities. Since specific language abilities are dissociable after stroke, the current study examines proportional recovery in individual language scores.

In 23 patients with ischemic or hemorrhagic stroke, acute (9-35 days after stroke) and chronic (0.66-8.8 years) scores on nine subtests of the Western Aphasia Battery (WAB), the Cognitive Linguistic Quick Test (CLQT), and the Boston Diagnostic Aphasia Examination (BDAE) were examined. Individual scores were missing for some patients, so the sample size ranged from 12 to 18 across tests. Multivariate regressions examined the relationship between actual aphasia recovery (acute to chronic change) for each score and the potential recovery, time to assessment, age, lesion size, education, and handedness.

 

Initial severity predicted the recovery for 6 of the 9 subscores analyzed, and explained 35-76% of the variance. In four of the subscores, lesion size also predicted recovery. The proportional recovery ranged from 0.08 to 0.73.

The proportional relationship between initial impairment and recovery was not constant across subscores. For tests of language comprehension, initial severity alone predicts the recovery score, and the proportional recovery rate was closer to the previously described 70%, whereas for measures of language production, initial severity in combination with lesion size predicts the recovery score with a lower proportional recovery rate. Larger sample sizes will be needed to determine the clinical applicability of these findings for aphasia prognosis.    

Authors/Disclosures
Melissa Bailey, MD
PRESENTER
Dr. Bailey has nothing to disclose.
Peter Turkeltaub, MD, PhD (Georgetown University) Dr. Turkeltaub has nothing to disclose.