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Abstract Details

Rare Presentation of CLL as Expansile Spinal Cord Lesions: ?A Radiographic Chronicle of Treatment Response
Neuro-oncology
P3 - Poster Session 3 (5:30 PM-6:30 PM)
7-005
NA
Both secondary lymphoma involvement of the spinal cord or primary spinal cord lymphoma are rare occurrences, estimated at 1% of primary CNS lymphoma. Due to variable presentation and high morbidity location for biopsy, diagnosis is often challenging. We present here a case diagnosed based on clinical suspicion, corresponding imaging, and treatment response.

69 year-old gentleman with bipolar disorder, secondary Parkinsonism and smoldering CLL presented after requiring a walker for new stiffness and gait slowing. He described ‘heavy’ right hip flexors and falls when taking turns. A few months later, he developed urinary retention, constipation, and peri-rectal numbness. On exam, patient had myeloradiculopathy and cauda equina syndrome. He had lower extremity spasticity, pathologic hyperreflexia, partial C4 sensory level, and slow spastic gait. He also had right L2-L4 sensory-motor radiculopathy with dysesthesia and iliopsoas weakness. Pre-existing secondary Parkinsonism tremors and cogwheel rigidity were mild.

MRI spine showed two lesions from medulla-C7 and T10-conus. Lesions were T2 hyperintense, and expanded both gray and white matter.  Gadolinium enhanced in a patchy, infiltrative pattern.  Cervical expansion was so severe it filled the spinal canal and effaced CSF space. MRI brain showed multiple post-contrast enhancements along the centrum semiovale concerning for perivascular infiltration of disease.  PET scan showed corresponding FDG avidity within spinal cord and extensive lymphadenopathy concerning for Richter’s transformation of CLL. The patient underwent induction with high dose methotrexate, vincristine, rituximab, and procarbazine (R-MPV). Due to methotrexate related nephrotoxicity, treatment was changed to rituximab, cyclophosphamide, doxorubicin, vincristine, procarbazine (R-CHO-procarbazine). After each cycle, there was marked radiographic response and clinical improvement.
This case highlights careful evaluation of neurologic symptoms in CLL, even in presence of comorbid neurologic conditions, such as extrapyramidal symptoms in our patient. Recognition of CNS involvement of CLL was critical in this case and has already achieved encouraging response to chemotherapy. 
Authors/Disclosures
Helen Spies, MD (Kaiser Permanente (Rock creek medical office))
PRESENTER
No disclosure on file
Amy Chan, MD (Dartmouth-Hitchcock Medical Center) Dr. Chan has nothing to disclose.