Abstract Details

Title Stroke In Population With Sleep Disturbance In Russia/Siberia: Gender Features. WHO Epidemiological Program MONICA-Psychosocial

Topic Sleep

Presentation(s) P3 - Poster Session 3 (5:30 PM-6:30 PM)

Poster/Presentation
Number 7-028

Objective To determine the gender differences in the effect of sleep disorders on risk of stroke in an open population 25-64 years in Russia/Siberia over 16 years of follow-up.

Background There are a few studies describing gender differences a risk of stroke in general population depending on sleep quality.

Design/Methods Under the third screening of WHO program MONICA -Psychosocial a random representative sample of both gender aged 25- 64 years in Novosibirsk was examined in 1994 (n=1346, male 48.8%, mean age 44,9 ± 0,4 years). The sleep assessment was performed using the Jenkins Sleep Questionnaire. There were 35 cases of new-onset stroke in women and 22 in men from 1994 to 2010. Univariate and multivariate regression model of Cox proportional hazards (Cox-regression) was used for risk assessments.

Results In an open population aged 25-64 years 48.6% of men and 65.9% of women had sleep disorders (p< 0.001). In univariate analysis risk of stroke was higher in men HR=3 (95%CI 1.2-7,6; p< 0,05) than in women HR=1,9 (95%CI 1,03 -3,7; p< 0,05). Multivariate analysis revealed in men with SD 2.8-fold risk of stroke (95%CI 1,1-7,1; p < 0,05) and women HR=2,7 (95%CI 1,4-5,42; p< 0,01). Stroke risk was higher in men with lower educational level and SD. There was an increase in the risk of stroke in women with a college education and SD HR=3.7 (95%CI 1,1 - 11,9; p< 0,05).

Conclusions

Our results demonstrated men with sleep disorders had higher risk of stroke than women. Social gradient increases cardiovascular risk in urban inhabitants with sleep disorders unequally.

Authors/Disclosures
PRESENTER	No disclosure on file
	No disclosure on file
	No disclosure on file
	No disclosure on file
	No disclosure on file
	No disclosure on file

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