Abstract Details

Title Sleep Quality Correlates with the Carotid intima-media Thickness in Stroke-free community-dwelling adults

Topic Sleep

Presentation(s) P3 - Poster Session 3 (5:30 PM-6:30 PM)

Poster/Presentation
Number 7-029

Objective

Objectives: We assessed the relationship between sleep quality and the carotid intima-media thickness (cIMT) in stroke-free individuals aged ≥40 years living in rural Ecuador.

Background Evidence of an association between sleep disorders and extracranial atherosclerosis is limited and has not been studied in rural settings, where living conditions and cardiovascular risk factors are different than in urban centers.

Design/Methods Using a population-based study design, participants underwent face-to-face interviews with the Pittsburgh Sleep Quality Index (PSQI) to assess sleep quality, and sonographic examinations for measurement of the carotid intima-media thickness (cIMT). The association between sleep quality (as the dependent variable) and the cIMT was assessed by means of generalized linear models, adjusted for relevant confounders.

Results The mean age of 561 participants was 60.4±12.6 years (58% women). The mean PSQI was 4.6±2.2 points. Seventy-nine (14%) individuals had an increased cIMT (>1 mm). A model adjusted for demographics showed a significant association between the PSQI score and increased cIMT (β: 0.602; 95% C.I.: 0.027 – 1.177; p=0.040). This relationship was reduced when cardiovascular risk factors were added to the model (β: 0.514; 95% C.I.: -0.072 – 1.101; p=0.086). When the model was adjusted for demographics and psychological distress, the association between the PSQI score and increased cIMT became significant (β: 0.573; 95% C.I.: 0.013 – 1.133; p=0.045), and both symptoms of depression (p=0.032) and anxiety (p<0.001) remained independently significant.

Conclusions

This study shows an association between the PSQI score and increased cIMT, which is, at least, partly mediated by manifestations of psychological distress.

Authors/Disclosures
Pablo R. Castillo, MD, FAAN (Mayo Clinic) PRESENTER	Dr. Castillo has nothing to disclose.
Oscar H. Del Brutto, MD, FAAN	Dr. Del Brutto has received research support from Universidad Espiritu Santo - Ecuador.

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