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Abstract Details

The Cumulative Effect of Partial Chronic Sleep Restriction on Objective Daytime Sleepiness in Neurologically Healthy Individuals
Sleep
P3 - Poster Session 3 (5:30 PM-6:30 PM)
7-040

The purpose of this study was to assess the level of sleepiness in individuals during and after partial chronic sleep restriction.

Excessive daytime sleepiness (EDS) is a common complaint in the general population, which is defined as the inability to stay awake and alert during the major waking episodes of the day. Limited studies have recorded the effects of partial chronic sleep restriction on objective measures of daytime somnolence.

Eighteen subjects underwent a sleep restriction and a control sleep sequence in random order. The sleep restriction sequence consisted of 3 nights of acclimation, then a 9 night experimental phase of restricted sleep (4 hours or less), followed by a 3 night recovery period of unrestricted sleep. In each phase, subjects underwent a maintenance of wakefulness test (MWT) and a single sleep latency test (SSLT) to determine objective daytime sleepiness during the sleep restricted and control sequence.

 Mean initial sleep latencies (ISL) for the SSLT and MWT were significantly lower for subjects during the experimental phase somnolence testing (ST) of the sleep restriction sequence than during the control sequence ST on each of the days (ST 2-4: p <0.03 for MWT and SSLT) The final experimental phase ST demonstrated the largest difference in mean ISLs between the restricted and control sequence (SSLT: 2.0 vs. 11.79. MWT: 7.29 vs. 42.56).  Within the restricted group, a significant recovery phase increase was observed for mean ISLs on the MWT and SSLT (ST 5-ST 6: p<0.001 for MWT and SSLT).

Partial chronic sleep restriction has a progressive impact on daytime sleepiness. However, after recovery sleep, daytime alertness is significantly recovered. These data may be helpful to further demonstrate the cumulative deleterious impact of chronic partial sleep restriction on daytime vigilance for patient counseling and public health initiatives concerning the importance of assuring sufficient sleep.

Authors/Disclosures
Fernanda Jacinto Pereira Teixeira, MD
PRESENTER
Dr. Jacinto Pereira Teixeira has nothing to disclose.
No disclosure on file
David Sandness, MD (University of Rochester Medical Center) Dr. Sandness has nothing to disclose.
No disclosure on file
Stuart J. McCarter, MD (Mayo Clinic) The institution of Dr. McCarter has received research support from NIH. The institution of Dr. McCarter has received research support from American Academy of Sleep Medicine Foundation.
No disclosure on file
Thomas Gossard, MD Mr. Gossard has nothing to disclose.
No disclosure on file
Virend Somers Virend Somers has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Jazz Pharmaceuticals. Virend Somers has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Lilly. Virend Somers has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Axome. Virend Somers has received personal compensation in the range of $500-$4,999 for serving as a Consultant for ApniMed. The institution of Virend Somers has received research support from National Institutes Health.
Erik K. St. Louis, MD (Mayo Clinic) The institution of Dr. St. Louis has received research support from NIH. Dr. St. Louis has received publishing royalties from a publication relating to health care. Dr. St. Louis has received publishing royalties from a publication relating to health care.