To study uric acid levels and Apo A1 levels in serum of patients suffering from Idiopathic Parkinson’s disease (IPD) and  Parkinson’s Plus syndromes (PPS) as a potential biomarker.

Premotor phase of Parkinson’s Disease and Parkinson Plus Syndromes starts decades before the onset of motor symptoms. Various fluid and tissue biomarkers are thought to play a role in the pathophysiology of these disorders.

A cross-sectional observational study was conducted at GMCH-32 and PGIMER, Chandigarh, India where cases of Idiopathic Parkinson’s Disease (IPD) and Parkinson Plus Syndromes (PPS) and healthy controls were recruited. The study cohort included 100 patients of IPD (n=77) and PPS (n=23), and 69 age and sex matched controls. All cases underwent detailed neurological examination, Hoehn and Yahr staging and MDS-UPDRS scoring. Serum of all cases and controls was collected for estimation of Uric acid levels and Apo A1 by ELISA.